D6808

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MedKoo CAT#: 122390

CAS#: N/A

Description: D6808 is a poatnet c-Met inhibitor, D6808 potently inhibited c-Met kinase and MET-amplified Hs746T gastric cancer cells with IC50 values of 2.9 and 0.7 nM, respectively. It also strongly suppressed Ba/F3-Tpr-Met cells harboring resistance-relevant mutations (F1200L/M1250T/H1094Y/F1200I/L1195V) with IC50 values of 4.2, 3.2, 1.0, 39.0, and 33.4 nM, respectively. Furthermore, D6808 exhibited extraordinary target specificity in a Kinome profiling against 373 wild-type kinases and served as a promising macrocycle-based compound for further anticancer drug development

Chemical Structure

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D6808
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 122390
Name: D6808
CAS#: N/A
Chemical Formula: C30H25F3N6O2
Exact Mass: 558.20
Molecular Weight: 558.570
Elemental Analysis: C, 64.51; H, 4.51; F, 10.20; N, 15.05; O, 5.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: D6808; D-6808; D 6808

IUPAC/Chemical Name: (14Z,52E)-63-(trifluoromethyl)-51,56-dihydro-11H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-56,7-dione

InChi Key: PQNIGFMNUHDZKX-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H25F3N6O2/c31-30(32,33)25-15-20-4-5-24(25)29(41)34-10-1-2-11-38-18-23(17-36-38)22-14-21-13-19(3-6-26(21)35-16-22)9-12-39-28(40)8-7-27(20)37-39/h3-8,13-18H,1-2,9-12H2,(H,34,41)

SMILES Code: O=C(C1=CC=C(C(C=C2)=NN(CCC3=CC4=CC5=CN=C4C=C3)C2=O)C=C1C(F)(F)F)NCCCCN6N=CC5=C6

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 558.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Wang C, Li J, Qu L, Tang X, Song X, Yang F, Chen X, Lin Q, Lin W, Zhou Y, Tu
Z, Chen Y, Zhang Z, Lu X. Discovery of D6808, a Highly Selective and Potent
Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene
Alteration Treatment. J Med Chem. 2022 Nov 24;65(22):15140-15164. doi:
10.1021/acs.jmedchem.2c00981. Epub 2022 Nov 10. PMID: 36355693.