WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 200270
CAS#: 658084-64-1 (free base)
Description: Daporinad, also known as APO-866 and FK866, is a small molecule with potential antineoplastic and antiangiogenic activities. NMPRTase inhibitor APO866 binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell prioduction of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis.
MedKoo Cat#: 200270
Name: Daporinad
CAS#: 658084-64-1 (free base)
Chemical Formula: C24H29N3O2
Exact Mass: 391.22598
Molecular Weight: 391.51
Elemental Analysis: C, 73.63; H, 7.47; N, 10.73; O, 8.17.
Daporinad free base, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Related CAS #: 658084-64-1 (free base) 201034-75-5 (free base) 1785666-54-7 (HCl) 1198425-96-5 (deleted)
Synonym: APO866; APO-866; APO 866; FK 866; FK-866; FK866; K 22.175; Daporinad;
IUPAC/Chemical Name: (E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
InChi Key: KPBNHDGDUADAGP-VAWYXSNFSA-N
InChi Code: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
SMILES Code: O=C(NCCCCC1CCN(C(C2=CC=CC=C2)=O)CC1)/C=C/C3=CC=CN=C3
The following data is based on the product molecular weight 391.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |