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MedKoo CAT#: 204320

CAS#: 1173699-31-4

Description: AMG 337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 750 Same day
200mg USD 1250 Same day
500mg USD 2150 Same day
1g USD 3250 2 Weeks
2g USD 5450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-30. Prices are subject to change without notice.

AMG-337, purity > 98%, is in stock. The same day shipping after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 204320
Name: AMG-337
CAS#: 1173699-31-4
Chemical Formula: C23H22FN7O3
Exact Mass: 463.1768
Molecular Weight: 463.4734
Elemental Analysis: C, 59.60; H, 4.78; F, 4.10; N, 21.16; O, 10.36

Synonym: AMG337; AMG-337; AMG 337.

IUPAC/Chemical Name: (R)-6-(1-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one


InChi Code: InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1

SMILES Code: O=C1C2=C(N=CC(OCCOC)=C2)C=CN1[C@@H](C3=NN=C4C(F)=CC(C5=CN(C)N=C5)=CN43)C

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information



  1: Lee J, Tran P, Klempner SJ. Targeting the MET Pathway in Gastric and
Oesophageal Cancers: Refining the Optimal Approach. Clin Oncol (R Coll Radiol).
2016 Feb 12. pii: S0936-6555(16)00035-2. doi: 10.1016/j.clon.2016.01.009. [Epub
ahead of print] PubMed PMID: 26880063.

2: Boezio AA, Copeland KW, Rex K, K Albrecht B, Bauer D, Bellon SF, Boezio C,
Broome MA, Choquette D, Coxon A, Dussault I, Hirai S, Lewis R, Lin MJ, Lohman J,
Liu J, Peterson EA, Potashman M, Shimanovich R, Teffera Y, Whittington DA, Vaida
KR, Harmange JC. Discovery of
l)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and
Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo
Antitumor Activity. J Med Chem. 2016 Feb 11. [Epub ahead of print] PubMed PMID:

3: Aprile G, Leone F, Giampieri R, Casagrande M, Marino D, Faloppi L, Cascinu S,
Fasola G, Scartozzi M. Tracking the 2015 Gastrointestinal Cancers Symposium:
bridging cancer biology to clinical gastrointestinal oncology. Onco Targets Ther.
2015 May 22;8:1149-56. doi: 10.2147/OTT.S82624. eCollection 2015. Review. PubMed
PMID: 26045669; PubMed Central PMCID: PMC4447178.