Almurtide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205943

CAS#: 61136-12-7 (free acid)

Description: Almurtide, also known as romurtide, is a synthetic muramyl dipeptide (MDP) H8analogue with potential immunostimulating and antineoplastic activity. As a derivative of the mycobacterial cell wall component MDP, almurtide activates both monocytes and macrophages. This results in the secretion of cytokines and induces the recruitment and activation of other immune cells, which may result in indirect tumoricidal or cytostatic effects.


Chemical Structure

img
Almurtide
CAS# 61136-12-7 (free acid)

Theoretical Analysis

MedKoo Cat#: 205943
Name: Almurtide
CAS#: 61136-12-7 (free acid)
Chemical Formula: C18H30N4O11
Exact Mass: 478.19111
Molecular Weight: 478.45
Elemental Analysis: C, 45.19; H, 6.32; N, 11.71; O, 36.78

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-03-02. Prices are subject to change without notice.

Almurtide,is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Related CAS #: 61136-12-7 (free acid)   103882-13-9 (sodium)    

Synonym: Almurtide; CGP 11637 ; CGP-11637 ; CGP11637; norMDP; norMDP;

IUPAC/Chemical Name: (4R)-4-((2S)-2-(2-(((3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)acetamido)propanamido)-5-amino-5-oxopentanoic acid

InChi Key: KCUSRWLYTAYGAU-KQSQHPHMSA-N

InChi Code: InChI=1S/C18H30N4O11/c1-7(17(30)22-9(16(19)29)3-4-12(26)27)20-11(25)6-32-15-13(21-8(2)24)18(31)33-10(5-23)14(15)28/h7,9-10,13-15,18,23,28,31H,3-6H2,1-2H3,(H2,19,29)(H,20,25)(H,21,24)(H,22,30)(H,26,27)/t7-,9+,10+,13+,14+,15+,18?/m0/s1

SMILES Code: O=C(O)CC[C@@H](NC([C@@H](NC(CO[C@@H]1[C@@H](NC(C)=O)C(O)O[C@H](CO)[C@H]1O)=O)C)=O)C(N)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 478.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ueda H, Yamazaki M. Induction of tumor necrosis factor-alpha in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide. Int Immunopharmacol. 2001 Jan;1(1):97-104. PubMed PMID: 11367521.

2: Yokouchi J, Hirabayashi S, Kanesaka N, Baba S, Amino M, Abe K. [Study on the most appropriate time for Romurtide administration (Nopia) in radiotherapy patients]. Gan To Kagaku Ryoho. 1997 Oct;24(13):1967-73. Japanese. PubMed PMID: 9350244.

3: Namba K, Yamamura E, Nitanai H, Otani T, Azuma I. Romurtide, a synthetic muramyl dipeptide derivative, promotes megakaryocytopoiesis through stimulation of cytokine production in nonhuman primates with myelosuppression. Vaccine. 1997 Mar;15(4):405-13. PubMed PMID: 9141212.

4: Namba K, Nitanai H, Otani T, Azuma I. Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model. Vaccine. 1996 Oct;14(14):1322-6. PubMed PMID: 9004440.

5: Namba K, Nakajima R, Otani T, Azuma I. Oral application of romurtide, a synthetic muramyl dipeptide derivative, stimulates nonspecific resistance to microbial infections and hematopoiesis in mice. Vaccine. 1996 Aug;14(12):1149-53. PubMed PMID: 8911012.

6: Yano K, Matsuoka H, Seo Y, Kounoe S, Saito T, Tomoda H. Restorative effect of romurtide for thrombocytopenia associated with intensive anticancer drug treatment and/or irradiation in patients with gastrointestinal cancer. Anticancer Res. 1995 Nov-Dec;15(6B):2883-7. PubMed PMID: 8669883.

7: Hasegawa J, Satoh A, Yagi K, Chida K. [Augmentation of immune defense mechanisms of the lung by romurtide]. Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Jun;33(6):605-11. Japanese. PubMed PMID: 7666614.

8: Azuma I, Otani T. Potentiation of host defense mechanism against infection by a cytokine inducer, an acyl-MDP derivative, MDP-Lys(L18) (romurtide) in mice and humans. Med Res Rev. 1994 Jul;14(4):401-14. Review. PubMed PMID: 8084203.

9: Suzuki K, Torii K, Hida S, Hayashi H, Hiyama Y, Oomoto Y, Takii T, Chiba T, Onozaki K. Differences in interleukin 1 (IL-1), IL-6, tumor necrosis factor and IL-1 receptor antagonist production by human monocytes stimulated with muramyl dipeptide (MDP) and its stearoyl derivative, romurtide. Immunopharmacology. 1994 Jul-Aug;28(1):31-8. PubMed PMID: 7928300.

10: Namba K, Otani T, Osada Y. Enhancement of platelet recovery in X-irradiated guinea pigs by romurtide, a synthetic muramyl dipeptide derivative. Blood. 1994 May 1;83(9):2480-8. PubMed PMID: 8167336.



Additional Information