ALB-109564

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 200131

CAS#: 1300114-12-8 (ALB-109564 dihydrochloride)

Description: ALB 109564(a) is a semi-synthetic derivative of the vinka alkaloid vinblastine with potential antineoplastic activity. Tubulin inhibitor ALB 109564(a) binds to tubulin monomers and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the G2/M phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).


Chemical Structure

img
ALB-109564
CAS# 1300114-12-8 (ALB-109564 dihydrochloride)

Theoretical Analysis

MedKoo Cat#: 200131
Name: ALB-109564
CAS#: 1300114-12-8 (ALB-109564 dihydrochloride)
Chemical Formula: C47H60N4O9S
Exact Mass:
Molecular Weight: 857.08
Elemental Analysis: C, 65.87; H, 7.06; N, 6.54; O, 16.80; S, 3.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ALB 109564(a). Vincaleukoblastine 12(methylthio) hydrochloride (1:2).

IUPAC/Chemical Name: (3aR,3a1R,4R,5S,5aR,10bR)-methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-13-(methylthio)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate.

InChi Key: JICBRHIOKVTMPJ-NEJRMLFWSA-N

InChi Code: InChI=1S/C47H60N4O9S/c1-9-43(55)23-28-24-46(41(53)58-6,37-30(14-18-50(25-28)26-43)31-20-29(61-8)12-13-34(31)48-37)33-21-32-35(22-36(33)57-5)49(4)39-45(32)16-19-51-17-11-15-44(10-2,38(45)51)40(60-27(3)52)47(39,56)42(54)59-7/h11-13,15,20-22,28,38-40,48,55-56H,9-10,14,16-19,23-26H2,1-8H3/t28-,38+,39-,40-,43+,44-,45-,46+,47+/m1/s1

SMILES Code: O=C([C@]1(O)[C@]2([H])N(C)C3=C(C=C([C@@]4(C(OC)=O)C[C@@]5([H])C[C@@](O)(CC)C[N@](C5)CCC6=C4NC7=C6C=C(SC)C=C7)C(OC)=C3)[C@]2(CCN8CC=C9)[C@]8([H])[C@]9(CC)[C@H]1OC(C)=O)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 857.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Milanowski DJ, Keilman J, Guo C, Mocek U. Isolation and identification of five impurities of ALB 109564(a) drug substance. J Pharm Biomed Anal. 2011 May 15;55(2):366-72. Epub 2011 Feb 3. PubMed PMID: 21353428.



Additional Information

Related:
1300114-12-8 (ALB-109564 dihydrochloride)
854756-74-4 (ALB-109564).

ALB 109564(a) is a novel analog from an established and marketed class of tubulin inhibitors, which is designed to kill cancer cells by preventing cell mitosis. In preclinical testing, the compound has a broad-spectrum effect in animal models, with efficacy superior to vinorelbine. Significant tumor growth delay was seen against human colon, lung and prostate solid tumors (as xenografts in mice) and against leukemia in mice. (source: http://www.amriglobal.com/pipeline/subpage.cfm?ID=19&subID=32).
 
ALB 109564(a) is an antimitotic agent and a semi-synthetic derivative of a natural product originally extracted from the Madagascar periwinkle flower. Antimitotic agents, used alone or most commonly in combination, continue to be an important part of cancer therapy; AMRI's tubulin inhibitor has potential to broaden this current arsenal. (source: http://www.amriglobal.com/pipeline/subpage.cfm?ID=19&subID=32).
 
 
Structures were from: AMRI 's website.