Pyromellitic dianhydride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208543

CAS#: 89-32-7

Description: Anhydrides are widely used as cross-linking agents in epoxy resins and alkyd production, for example, as coatings and adhesives in plastic products. Sensitisation to several anhydrides is known to cause occupational asthma. There are indications that the lesser known pyromellitic dianhydride (PMDA) can cause irritative respiratory symptoms and possibly asthma. Recently, researches found crosslinking pyromellitic dianhydride (PMDA) with cyclodestrin polymers have been found to have anti-HIV-1 activity

Chemical Structure

Pyromellitic dianhydride
CAS# 89-32-7

Theoretical Analysis

MedKoo Cat#: 208543
Name: Pyromellitic dianhydride
CAS#: 89-32-7
Chemical Formula: C10H2O6
Exact Mass: 217.99
Molecular Weight: 218.120
Elemental Analysis: C, 55.07; H, 0.92; O, 44.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Pyromellitic dianhydride, Benzene-1,2,4,5-tetracarboxylic dianhydride, EINECS 201-898-9, HSDB 6950, NSC 4798,

IUPAC/Chemical Name: 1,2,4,5-Benzenetetracarboxylic 1,2:4,5-dianhydride


InChi Code: InChI=1S/C10H2O6/c11-7-3-1-4-6(10(14)16-8(4)12)2-5(3)9(13)15-7/h1-2H

SMILES Code: O=C(O1)C2=CC(C3=O)=C(C(O3)=O)C=C2C1=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 218.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Adeoye O, Bártolo I, Conceição J, da Silva AB, Duarte N, Francisco AP, Taveira N, Cabral-Marques H. Pyromellitic dianhydride crosslinked soluble cyclodextrin polymers: Synthesis, lopinavir release from sub-micron sized particles and anti-HIV-1 activity. Int J Pharm. 2020 Jun 15;583:119356. doi: 10.1016/j.ijpharm.2020.119356. Epub 2020 Apr 20. PMID: 32325245.

2: Madsen MT, Skadhauge LR, Nielsen AD, Baelum J, Sherson DL. Pyromellitic dianhydride (PMDA) may cause occupational asthma. Occup Environ Med. 2019 Mar;76(3):175-177. doi: 10.1136/oemed-2018-105295. Epub 2019 Jan 11. PMID: 30635433; PMCID: PMC6581108.

3: Rafati N, Zarrabi A, Caldera F, Trotta F, Ghias N. Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations. J Microencapsul. 2019 Dec;36(8):715-727. doi: 10.1080/02652048.2019.1669728. Epub 2019 Sep 27. PMID: 31530203.

4: Kozieł K, Łagiewka J, Girek B, Folentarska A, Girek T, Ciesielski W. Synthesis of New Amino-β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles. Polymers (Basel). 2021 Apr 19;13(8):1332. doi: 10.3390/polym13081332. PMID: 33921681; PMCID: PMC8073293.

5: Vermeulen D, Corbin N, Goetz KP, Jurchescu OD, Coropceanu V, McNeil LE. Electron-phonon coupling in anthracene-pyromellitic dianhydride. J Chem Phys. 2017 Jun 7;146(21):214705. doi: 10.1063/1.4984268. PMID: 28595390.

6: Li Y, Jiang Z, Dong G, Ho W. Construction and Activity of an All-Organic Heterojunction Photocatalyst Based on Melem and Pyromellitic Dianhydride. ChemSusChem. 2022 Jun 22;15(12):e202200875. doi: 10.1002/cssc.202200875. Epub 2022 Jun 2. PMID: 35655290.

7: Guo Y, Wang R, Yan C, Wang P, Rao L, Wang C. Developing boron nitride- pyromellitic dianhydride composite for removal of aromatic pollutants from wastewater via adsorption and photodegradation. Chemosphere. 2019 Aug;229:112-124. doi: 10.1016/j.chemosphere.2019.04.196. Epub 2019 May 2. PMID: 31078026.

8: Deng J, Liu Y, Liu S, Zeng G, Tan X, Huang B, Tang X, Wang S, Hua Q, Yan Z. Competitive adsorption of Pb(II), Cd(II) and Cu(II) onto chitosan-pyromellitic dianhydride modified biochar. J Colloid Interface Sci. 2017 Nov 15;506:355-364. doi: 10.1016/j.jcis.2017.07.069. Epub 2017 Jul 18. PMID: 28750237.

9: Li Y, Jiang Z, Dong G, Ho W. Construction and Activity of an All-Organic Heterojunction Photocatalyst Based on Melem and Pyromellitic Dianhydride. ChemSusChem. 2022 Jun 22;15(12):e202200477. doi: 10.1002/cssc.202200477. Epub 2022 Apr 29. PMID: 35485996.

10: Konieczny S, Fik CP, Averesch NJ, Tiller JC. Organosoluble enzyme conjugates with poly(2-oxazoline)s via pyromellitic acid dianhydride. J Biotechnol. 2012 Jun 15;159(3):195-203. doi: 10.1016/j.jbiotec.2012.01.016. Epub 2012 Jan 26. PMID: 22306109.