Macimorelin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205797

CAS#: 381231-18-1

Description: Macimorelin, also known as AEZS-130, EP-1572, or JMV1843, is a novel synthetic small molecule, acting as a ghrelin agonist, that is orally active and stimulates the secretion of growth hormone (GH). Based on results of Phase 1 studies, AEZS-130 has potential applications for the treatment of cachexia, a condition frequently associated with severe chronic diseases such as cancer, chronic obstructive pulmonary disease and AIDS. In addition to the therapeutic application, a Phase 3 trial with AEZS-130 as a diagnostic test for growth hormone deficiencies in adults has been completed.


Price and Availability

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10mg
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100mg
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1g
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25mg
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200mg
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2g
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50mg
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500mg
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5g
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Macimorelin is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205797
Name: Macimorelin
CAS#: 381231-18-1
Chemical Formula: C26H30N6O3
Exact Mass: 474.23794
Molecular Weight: 474.5548
Elemental Analysis: C, 65.80; H, 6.37; N, 17.71; O, 10.11


Synonym: JMV1843; JMV-1843; JMV 1843; AEZS-130; AEZS 130; AEZS130; EP-1572; EP 1572; EP1572; UMV-1843; UMV 1843; Macimorelin; AibDTrpDgTrpCHO.

IUPAC/Chemical Name: 2-amino-N-((R)-1-(((R)-1-formamido-2-(1H-indol-3-yl)ethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methylpropanamide

InChi Key: UJVDJAPJQWZRFR-DHIUTWEWSA-N

InChi Code: InChI=1S/C26H30N6O3/c1-26(2,27)25(35)31-22(11-16-13-28-20-9-5-3-7-18(16)20)24(34)32-23(30-15-33)12-17-14-29-21-10-6-4-8-19(17)21/h3-10,13-15,22-23,28-29H,11-12,27H2,1-2H3,(H,30,33)(H,31,35)(H,32,34)/t22-,23-/m1/s1

SMILES Code: CC(C)(N)C(N[C@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](NC=O)CC3=CNC4=C3C=CC=C4)=O)=O


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

AEZS-130 (EP-1572) is a novel peptidomimetic growth hormone secretagogues (GHS) which represent a new class of pharmacological agents which have the potential to be used in numerous clinical applications. They include treatment for growth retardation in children and cachexia associated with chronic disease such as AIDS and cancer.
  
Following the successfull Phase 3 trial results in AGHD, for which orphan-drug status had been granted by the FDA in 2007, the Company expects to file a new drug application (NDA) in 2012. (source:http://www.aezsinc.com/en/page.php?p=31&prod=46).
 
 


References

1: Agrawal V, Garcia JM. The macimorelin-stimulated growth hormone test for adult growth hormone deficiency diagnosis. Expert Rev Mol Diagn. 2014 Jul;14(6):647-54. doi: 10.1586/14737159.2014.915746. Epub 2014 May 16. PubMed PMID: 24834478.

2: Garcia JM, Swerdloff R, Wang C, Kyle M, Kipnes M, Biller BM, Cook D, Yuen KC, Bonert V, Dobs A, Molitch ME, Merriam GR. Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab. 2013 Jun;98(6):2422-9. doi: 10.1210/jc.2013-1157. Epub 2013 Apr 4. PubMed PMID: 23559086