WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 201475

CAS#: 949963-04-6

Description: AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.

Chemical Structure

CAS# 949963-04-6

Theoretical Analysis

MedKoo Cat#: 201475
Name: AEG40826
CAS#: 949963-04-6
Chemical Formula: C58H80N10O8
Exact Mass: 1,044.62
Molecular Weight: 1,045.340
Elemental Analysis: C, 66.64; H, 7.71; N, 13.40; O, 12.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: HGS1029; HGS-1029; HGS 1029; AEG40826; AEG-40826; AEG 40826; AEG408262 HCl.

IUPAC/Chemical Name: N1,N4-bis((3S,5S)-1-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)terephthalamide


InChi Code: InChI=1S/C58H80N10O8/c1-33(59-9)49(69)65-47(57(3,4)5)55(75)67-31-39(29-45(67)53(73)63-43-23-15-19-35-17-11-13-21-41(35)43)61-51(71)37-25-27-38(28-26-37)52(72)62-40-30-46(54(74)64-44-24-16-20-36-18-12-14-22-42(36)44)68(32-40)56(76)48(58(6,7)8)66-50(70)34(2)60-10/h11-14,17-18,21-22,25-28,33-34,39-40,43-48,59-60H,15-16,19-20,23-24,29-32H2,1-10H3,(H,61,71)(H,62,72)(H,63,73)(H,64,74)(H,65,69)(H,66,70)/t33-,34-,39-,40-,43+,44+,45-,46-,47+,48+/m0/s1

SMILES Code: C[C@H](NC)C(N[C@H](C(N1C[C@@H](NC(C2=CC=C(C(N[C@@H](C[C@H]3C(N[C@@H]4CCCC5=C4C=CC=C5)=O)CN3C([C@H](C(C)(C)C)NC([C@@H](NC)C)=O)=O)=O)C=C2)=O)C[C@H]1C(N[C@@H]6CCCC7=C6C=CC=C7)=O)=O)C(C)(C)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1045.340000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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