SX-576

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208447

CAS#: 1240494-14-7

Description: SX-576 is undergoing further investigation as a potential therapy for pulmonary inflammation. It is also a potent non-competitive boronic acid-containing CXCR1/2 antagonists.

Chemical Structure

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SX-576
CAS# 1240494-14-7
Instruction

Theoretical Analysis

MedKoo Cat#: 208447
Name: SX-576
CAS#: 1240494-14-7
Chemical Formula: C20H15BF4N2O4S
Exact Mass: 466.08
Molecular Weight: 466.210
Elemental Analysis: C, 51.53; H, 3.24; B, 2.32; F, 16.30; N, 6.01; O, 13.73; S, 6.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SX576

IUPAC/Chemical Name: 6-(2-Boronic acid-5-trifluoromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide

InChi Key: AEDMWJARWOMJKQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28)

SMILES Code: FC1=CC=C(NC(C2=CC=C(SCC3=CC(OC(F)(F)F)=CC=C3B(O)O)N=C2)=O)C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 466.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Maeda DY, Peck AM, Schuler AD, Quinn MT, Kirpotina LN, Wicomb WN, Auten RL, Gundla R, Zebala JA. Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2280-4. doi: 10.1016/j.bmcl.2015.04.041. Epub 2015 Apr 23. PMID: 25933594; PMCID: PMC4430358.