WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205897
Description: AC430 is a potent and specific small molecule inhibitor of janus kinase 2 (JAK2), which has been implicated as a target for therapy in both oncology and autoimmune disease. AC430 is currently being developed by Ambit. In preclinical studies, AC430 has exhibited potency against JAK2 and V617F mutated JAK2 in cell-based models that is at least equivalent to, and in most cases superior to, competing JAK2 inhibitors. In preclinical oncology and autoimmune models, AC430 is well tolerated and has significant efficacy at oral doses as low as 10 mg/kg/day.
MedKoo Cat#: 205897
Chemical Formula: C19H16FN5O
Exact Mass: 349.13389
Molecular Weight: 349.37
Elemental Analysis: C, 65.32; H, 4.62; F, 5.44; N, 20.05; O, 4.58
AC430 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: AC430; AC-430; AC 430.
IUPAC/Chemical Name: (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol
InChi Key: DCRWIATZWHLIPN-KRWDZBQOSA-N
InChi Code: InChI=1S/C19H16FN5O/c1-11-10-16(25-24-11)22-18-14-4-2-3-5-15(14)21-19(23-18)17(26)12-6-8-13(20)9-7-12/h2-10,17,26H,1H3,(H2,21,22,23,24,25)/t17-/m0/s1
SMILES Code: CC1=CC(NC2=NC([C@@H](O)C3=CC=C(F)C=C3)=NC4=C2C=CC=C4)=NN1
The following data is based on the product molecular weight 349.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
(Note: Structure of AC-430 was from http://chem.sis.nlm.nih.gov/chemidplus/rn/1361415-84-0)