WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206211
CAS#: 286845-00-9
Description: ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis.
MedKoo Cat#: 206211
Name: ABT-518
CAS#: 286845-00-9
Chemical Formula: C21H22F3NO8S
Exact Mass: 505.10182
Molecular Weight: 505.46
Elemental Analysis: C, 49.90; H, 4.39; F, 11.28; N, 2.77; O, 25.32; S, 6.34
ABT-518 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: ABT518; ABT 518; ABT-518.
IUPAC/Chemical Name: N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl)-N-hydroxyformamide
InChi Key: IVPPTWCRAFCOFJ-RTBURBONSA-N
InChi Code: InChI=1S/C21H22F3NO8S/c1-20(2)30-11-19(33-20)18(25(27)13-26)12-34(28,29)17-9-7-15(8-10-17)31-14-3-5-16(6-4-14)32-21(22,23)24/h3-10,13,18-19,27H,11-12H2,1-2H3/t18-,19-/m1/s1
SMILES Code: O=CN([C@@H]([C@@H]1OC(C)(C)OC1)CS(=O)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O)O
The following data is based on the product molecular weight 505.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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6: Crul M, Beerepoot LV, Stokvis E, Vermaat JS, Rosing H, Beijnen JH, Voest EE, Schellens JH. Clinical pharmacokinetics, pharmacodynamics and metabolism of the novel matrix metalloproteinase inhibitor ABT-518. Cancer Chemother Pharmacol. 2002 Dec;50(6):473-8. Epub 2002 Oct 25. PubMed PMID: 12451474.
7: Gum RJ, Hickman D, Fagerland JA, Heindel MA, Gagne GD, Schmidt JM, Michaelides MR, Davidsen SK, Ulrich RG. Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1). Biochem Pharmacol. 2001 Dec 15;62(12):1661-73. PubMed PMID: 11755120.
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ABT-518 is a potent inhibitor of gelatinase A and gelatinase B, two matrix metalloproteinase (MMP) enzymes involved in tumor growth and metastasis. ABT-518 has demonstrated robust antitumor activity in a variety of animal models. This compound is a potent and selective inhibitor of these enzyme targets.
