WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 121012
Description: WB-156 is a MDM2 PROTAC (IC50= 3.2 nM) that induces degradation of MDM2.
MedKoo Cat#: 121012
Chemical Formula: C48H48Cl2N6O5
Exact Mass: 858.3063
Molecular Weight: 859.85
Elemental Analysis: C, 67.05; H, 5.63; Cl, 8.25; N, 9.77; O, 9.30
This product is not in stock, which may be available by custom synthesis.
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Synonym: WB-156; WB156; WB 156
IUPAC/Chemical Name: 3-(4-(3-(4-((4S,5R)-2-(4-(tert-butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)prop-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChi Key: SXPSRFOBNYZXKH-UZLVNVLGSA-N
InChi Code: InChI=1S/C48H48Cl2N6O5/c1-5-61-40-28-33(48(2,3)4)15-20-37(40)44-52-42(31-11-16-34(49)17-12-31)43(32-13-18-35(50)19-14-32)56(44)47(60)54-26-24-53(25-27-54)23-7-9-30-8-6-10-36-38(30)29-55(46(36)59)39-21-22-41(57)51-45(39)58/h6,8,10-20,28,39,42-43H,5,21-27,29H2,1-4H3,(H,51,57,58)/t39?,42-,43+/m0/s1
SMILES Code: ClC1=CC=C([C@@H]2[C@H](C3=CC=C(Cl)C=C3)N=C(C4=C(OCC)C=C(C(C)(C)C)C=C4)N2C(N5CCN(CC#CC6=C(CN(C7C(NC(CC7)=O)=O)C8=O)C8=CC=C6)CC5)=O)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 859.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|