WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208348
CAS#: unknown
Description: PTX80 is a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer
MedKoo Cat#: 208348
Name: PTX80
CAS#: unknown
Chemical Formula: C26H26N4O3S
Exact Mass: 474.1726
Molecular Weight: 474.58
Elemental Analysis: C, 65.80; H, 5.52; N, 11.81; O, 10.11; S, 6.76
This product is not in stock, which may be available by custom synthesis.
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Synonym: PTX-80
IUPAC/Chemical Name: 4,4'-((1E,1'E)-(1-((3-(Dimethylamino)propyl)sulfonyl)-4-oxopiperidine-3,5-diylidene)bis(methaneylylidene))dibenzonitrile
InChi Key: ACOAFAKBTXAOQG-KOJZRSEWSA-N
InChi Code: InChI=1S/C26H26N4O3S/c1-29(2)12-3-13-34(32,33)30-18-24(14-20-4-8-22(16-27)9-5-20)26(31)25(19-30)15-21-6-10-23(17-28)11-7-21/h4-11,14-15H,3,12-13,18-19H2,1-2H3/b24-14+,25-15+
SMILES Code: CN(C)CCCS(N(C/C1=C\C2=CC=C(C#N)C=C2)C/C(C1=O)=C\C3=CC=C(C#N)C=C3)(=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 474.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Kalid O, Gotliv I, Levy-Apter E, Beker DF, Cherniavsky-Lev M, Rotem E, Miron N. PTX80, A Novel Compound Targeting the Autophagy Receptor p62/SQSTM1 for Treatment of Cancer. Chem Biol Drug Des. 2022 Mar 24. doi: 10.1111/cbdd.14046. Epub ahead of print. PMID: 35322538.
Takayama S, Ueno H, Kawaguchi S, Asahara F, Hoshimoto S, Harada H, Ogawa S, Sato M, Matsui J, Ando N. [A case of bone marrow carcinomatosis from breast cancer treated with weekly Paclitaxel]. Gan To Kagaku Ryoho. 2012 Jan;39(1):99-101. Japanese. PMID: 22241360.
