F114

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208288

CAS#: unknown

Description: F114 is a novel, first-in-class, dual aurora and lim kinase inhibitor. Using in vitro and ex vivo models of GBM, researchers found that F114 inhibits GBM proliferation and invasion. These results establish F114 as a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future drug development efforts for GBM, and potentially other cancers.

Chemical Structure

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F114
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 208288
Name: F114
CAS#: unknown
Chemical Formula: C16H20N6O
Exact Mass: 312.17
Molecular Weight: 312.380
Elemental Analysis: C, 61.52; H, 6.45; N, 26.90; O, 5.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: F-114, F1-14, F11-4

IUPAC/Chemical Name: 8-Isopropyl-2-((1-isopropyl-1H-pyrazol-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

InChi Key: WANOQCJEBRGYPS-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H20N6O/c1-10(2)21-9-13(8-18-21)19-16-17-7-12-5-6-14(23)22(11(3)4)15(12)20-16/h5-11H,1-4H3,(H,17,19,20)

SMILES Code: CC(C)N1N=CC(NC2=NC(N(C(C)C)C(C=C3)=O)=C3C=N2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 312.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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3: Rybin MJ, Laverde-Paz MJ, Suter RK, Affer M, Ayad NG, Feng Y, Zeier Z. A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion. Bioorg Med Chem Lett. 2022 Apr 1;61:128614. doi: 10.1016/j.bmcl.2022.128614. Epub 2022 Feb 10. PMID: 35151865.


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