V11294A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208249

CAS#: 162278-10-6

Description: V11294A is a novel PDE4 inhibitor. A single oral 300 mg dose of V11294A administered to healthy volunteers results in plasma concentrations adequate to inhibit activation of inflammatory cells ex vivo, which persists for at least 24 h without any adverse reactions

Chemical Structure

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V11294A
CAS# 162278-10-6
Instruction

Theoretical Analysis

MedKoo Cat#: 208249
Name: V11294A
CAS#: 162278-10-6
Chemical Formula: C23H32ClN5O2
Exact Mass: 445.22
Molecular Weight: 445.990
Elemental Analysis: Chemical Formula: C23H32ClN5O2 Exact Mass: 445.2245 Molecular Weight: 445.9920 Elemental Analysis: C, 61.94; H, 7.23; Cl, 7.95; N, 15.70; O, 7.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: V-11294A, V11-294A, V11294-A

IUPAC/Chemical Name: 6-Ethylamino-3-(3-Cyclopentyloxy-4-methoxybenzyl)-8-isopropyl-3H-purine hydrochloride

InChi Key: UUAPXPGCDROOPM-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H31N5O2.ClH/c1-5-24-22-20-23(27-21(26-20)15(2)3)28(14-25-22)13-16-10-11-18(29-4)19(12-16)30-17-8-6-7-9-17;/h10-12,14-15,17,24H,5-9,13H2,1-4H3;1H

SMILES Code: 6-Ethylamino-3-(3-Cyclopentyloxy-4-methoxybenzyl)-8-isopropyl-3H-purine hydrochloride

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Gale DD, Landells LJ, Spina D, Miller AJ, Smith K, Nichols T, Rotshteyn Y, Tonelli A, Lacouture P, Burch RM, Page CP, O'Connor BJ. Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol. 2002 Nov;54(5):478-84. doi: 10.1046/j.1365-2125.2002.01682.x. PMID: 12445026; PMCID: PMC1874476.
Abdollahi M, Chan TS, Subrahmanyam V, O'Brien PJ. Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol Cell Biochem. 2003 Oct;252(1-2):205-11. doi: 10.1023/a:1025568714217. PMID: 14577594.

Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. doi: 10.1038/bjp.2008.297. Epub 2008 Jul 28. PMID: 18660832; PMCID: PMC2567889.