WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 208244
CAS#: unknown
Description: G613 has shown growth inhibitory activity in breast cancer cells. Additionally, the compound decreased estrogen receptor activity through sequestration of estrogen receptor α by p53 thereby causing a decreased transcriptional activation and expression of proliferation markers. In conclusion, G613 represents a potent small-molecule inhibitor of the Mdm2-p53 interaction and can serve as a promising lead for developing a new class of anti-cancer therapy for breast cancer patients.
MedKoo Cat#: 208244
Name: G613
CAS#: unknown
Chemical Formula: C36H34ClN3O4
Exact Mass: 607.2238
Molecular Weight: 607.14
Elemental Analysis: C, 71.10; H, 5.64; Cl, 5.83; N, 6.91; O, 10.52
This product is not in stock, which may be available by custom synthesis.
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Synonym: G-613, G6-13, G61-3
IUPAC/Chemical Name: 5-Chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one
InChi Key: QPWWUAQNASGKKV-LABVJWKOSA-N
InChi Code: InChI=1S/C36H34ClN3O4/c37-27-13-16-29-30(23-27)38-35(42)36(29)32(31(24-7-3-1-4-8-24)33(39-36)25-9-5-2-6-10-25)34(41)26-11-14-28(15-12-26)44-22-19-40-17-20-43-21-18-40/h1-16,23,31-33,39H,17-22H2,(H,38,42)/t31-,32+,33+,36-/m0/s1
SMILES Code: O=C1NC2=C([C@]31N[C@H](C4=CC=CC=C4)[C@@H](C5=CC=CC=C5)[C@@H]3C(C6=CC=C(OCCN7CCOCC7)C=C6)=O)C=CC(Cl)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 607.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Saxena R, Gupta G, Manohar M, Debnath U, Popli P, Prabhakar YS, Konwar R, Kumar S, Kumar A, Dwivedi A. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. Int J Biochem Cell Biol. 2016 Jan;70:105-17. doi: 10.1016/j.biocel.2015.11.003. Epub 2015 Nov 7. PMID: 26556313.
2: Krüger L, Pridgen TA, Taylor ER, Garman KS, Blikslager AT. Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus. Am J Physiol Gastrointest Liver Physiol. 2020 Apr 1;318(4):G613-G623. doi: 10.1152/ajpgi.00086.2019. Epub 2020 Feb 18. PMID: 32068440; PMCID: PMC7191458.
3: Floccari LV, Jeans KA, Herring JA, Johnston CE, Karol LA. Comparison of Outcomes by Reconstructive Strategy in Patients with Prostheses for Proximal Femoral Focal Deficiency. J Bone Joint Surg Am. 2021 Oct 6;103(19):1817-1825. doi: 10.2106/JBJS.20.02001. PMID: 34270496.
4: Van Klinken BJ, Dekker J, Büller HA, Einerhand AW. Mucin gene structure and expression: protection vs. adhesion. Am J Physiol. 1995 Nov;269(5 Pt 1):G613-27. doi: 10.1152/ajpgi.1995.269.5.G613. PMID: 7491952.
5: Mao Y, Zhang Z, Wong B. Use of green fluorescent protein fusions to analyse the N- and C-terminal signal peptides of GPI-anchored cell wall proteins in Candida albicans. Mol Microbiol. 2003 Dec;50(5):1617-28. doi: 10.1046/j.1365-2958.2003.03794.x. PMID: 14651643.
6: Kizu T, Yoshida Y, Furuta K, Ogura S, Egawa M, Chatani N, Hamano M, Takemura T, Ezaki H, Kamada Y, Nishida K, Nakaoka Y, Kiso S, Takehara T. Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G613-24. doi: 10.1152/ajpgi.00289.2014. Epub 2015 Jan 23. PMID: 25617348.
7: Meir M, Flemming S, Burkard N, Bergauer L, Metzger M, Germer CT, Schlegel N. Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G613-24. doi: 10.1152/ajpgi.00357.2014. Epub 2015 Aug 20. PMID: 26294673.
8: Otte JM, Podolsky DK. Functional modulation of enterocytes by gram-positive and gram-negative microorganisms. Am J Physiol Gastrointest Liver Physiol. 2004 Apr;286(4):G613-26. doi: 10.1152/ajpgi.00341.2003. PMID: 15010363.
9: Donadio-Moura J, Gouw-Soares S, de Freitas PM, Navarro RS, Powell LG, Eduardo Cde P. Tensile bond strength of a flowable composite resin to ER:YAG-laser- treated dentin. Lasers Surg Med. 2005 Jun;36(5):351-5. doi: 10.1002/lsm.20176. PMID: 15825207.
10: Ewart WR, Wingate DL. Cholecystokinin octapeptide and gastric mechanoreceptor activity in rat brain. Am J Physiol. 1983 Jun;244(6):G613-7. doi: 10.1152/ajpgi.1983.244.6.G613. PMID: 6305211.
