p38 MAP modulator

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208201

CAS#: 773104-07-7

Description: p38 MAP modulator is a modulator for p38 Mitogen-Activated Protein (MAP) kinase, a serine/threonine kinase, which is known as one of the best characterized kinases in the inflammatory process


Chemical Structure

img
p38 MAP modulator
CAS# 773104-07-7

Theoretical Analysis

MedKoo Cat#: 208201
Name: p38 MAP modulator
CAS#: 773104-07-7
Chemical Formula: C19H13ClF2N2O4
Exact Mass: 406.0532
Molecular Weight: 406.77
Elemental Analysis: C, 56.10; H, 3.22; Cl, 8.72; F, 9.34; N, 6.89; O, 15.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: p38MAP modulator, p38MAPmodulator

IUPAC/Chemical Name: 3-[5-Chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoic acid

InChi Key: GEFBZDGWNJSLQF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H13ClF2N2O4/c1-10-2-3-11(19(26)27)6-15(10)24-9-23-17(16(20)18(24)25)28-8-12-4-5-13(21)7-14(12)22/h2-7,9H,8H2,1H3,(H,26,27)

SMILES Code: O=C(O)C1=CC=C(C)C(N(C=NC(OCC2=CC=C(F)C=C2F)=C3Cl)C3=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 406.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Chen T, Zhang WW, Chu YX, Wang YQ. Acupuncture for Pain Management: Molecular Mechanisms of Action. Am J Chin Med. 2020;48(4):793-811. doi: 10.1142/S0192415X20500408. Epub 2020 May 15. PMID: 32420752.

2: Koul HK, Pal M, Koul S. Role of p38 MAP Kinase Signal Transduction in Solid Tumors. Genes Cancer. 2013 Sep;4(9-10):342-59. doi: 10.1177/1947601913507951. PMID: 24349632; PMCID: PMC3863344.

3: Topolska-Woś AM, Rosińska S, Filipek A. MAP kinase p38 is a novel target of CacyBP/SIP phosphatase. Amino Acids. 2017 Jun;49(6):1069-1076. doi: 10.1007/s00726-017-2404-7. Epub 2017 Mar 10. PMID: 28283909; PMCID: PMC5437258.

4: Amir M, Somakala K, Ali S. p38 MAP kinase inhibitors as anti inflammatory agents. Mini Rev Med Chem. 2013 Dec;13(14):2082-96. doi: 10.2174/13895575113136660098. PMID: 24107108.

5: Park J, Min JS, Kim B, Chae UB, Yun JW, Choi MS, Kong IK, Chang KT, Lee DS. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways. Neurosci Lett. 2015 Jan 1;584:191-6. doi: 10.1016/j.neulet.2014.10.016. Epub 2014 Oct 22. PMID: 25459294.

6: Park EC, Rongo C. The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons. Elife. 2016 Jan 5;5:e12010. doi: 10.7554/eLife.12010. PMID: 26731517; PMCID: PMC4775213.

7: Tanaka H, Sawano T, Konishi N, Harada R, Takeuchi C, Shin Y, Sugiura H, Nakatani J, Fujimoto T, Yamagata K. Serotonin induces Arcadlin in hippocampal neurons. Neurosci Lett. 2020 Mar 16;721:134783. doi: 10.1016/j.neulet.2020.134783. Epub 2020 Jan 22. PMID: 31981722.

8: Nakamura M, Chikama T, Nishida T. Participation of p38 MAP kinase, but not p44/42 MAP kinase, in stimulation of corneal epithelial migration by substance P and IGF-1. Curr Eye Res. 2005 Oct;30(10):825-34. doi: 10.1080/02713680591006129. PMID: 16251119.

9: Khatiwada S, Delhon G, Chaulagain S, Rock DL. The novel ORFV protein ORFV113 activates LPA-p38 signaling. PLoS Pathog. 2021 Oct 6;17(10):e1009971. doi: 10.1371/journal.ppat.1009971. PMID: 34614034; PMCID: PMC8523077.

10: Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG. p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability. J Clin Invest. 2001 Nov;108(10):1495-504. doi: 10.1172/JCI12190. PMID: 11714741; PMCID: PMC209415