WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 25146
CAS#: 873546-38-4
Description: T-2307 is an aromatic diamidine currently in development for the treatment of invasive fungal infections. This agent has been shown to selectively cause the collapse of the mitochondrial membrane potential in yeasts when compared to mammalian cells. In vitro activity has been demonstrated against Candida species, including C. albicans, C. glabrata, and C. auris strains, which are resistant to azole and echinocandin antifungals
MedKoo Cat#: 25146
Name: T-2307
CAS#: 873546-38-4
Chemical Formula: C25H48Cl3N5O7
Exact Mass: 635.2619
Molecular Weight: 637.04
Elemental Analysis: C, 47.14; H, 7.60; Cl, 16.69; N, 10.99; O, 17.58
This product is not in stock, which may be available by custom synthesis.
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Synonym: T2307, T 2307, T-230-7
IUPAC/Chemical Name: 4-[3-[1-[3-(4-Carbamimidoylphenoxy)propyl]piperidin-4-yl]propoxy]benzenecarboximidamide pentahydrate trihydrochloride
InChi Key: DIOMKOCDIBAKRN-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H35N5O2.3ClH.5H2O/c26-24(27)20-4-8-22(9-5-20)31-17-1-3-19-12-15-30(16-13-19)14-2-18-32-23-10-6-21(7-11-23)25(28)29;;;;;;;;/h4-11,19H,1-3,12-18H2,(H3,26,27)(H3,28,29);3*1H;5*1H2
SMILES Code: N=C(C1=CC=C(OCCCC2CCN(CCCOC3=CC=C(C(N)=N)C=C3)CC2)C=C1)N.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]Cl.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 637.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wiederhold NP. Review of T-2307, an Investigational Agent That Causes Collapse of Fungal Mitochondrial Membrane Potential. J Fungi (Basel). 2021 Feb 11;7(2):130. doi: 10.3390/jof7020130. PMID: 33670132; PMCID: PMC7916847.
2: Abe M, Nakamura S, Kinjo Y, Masuyama Y, Mitsuyama J, Kaku M, Miyazaki Y. Efficacy of T-2307, a novel arylamidine, against ocular complications of disseminated candidiasis in mice. J Antimicrob Chemother. 2019 May 1;74(5):1327-1332. doi: 10.1093/jac/dkz020. PMID: 30753506.
3: Yamashita K, Miyazaki T, Fukuda Y, Mitsuyama J, Saijo T, Shimamura S, Yamamoto K, Imamura Y, Izumikawa K, Yanagihara K, Kohno S, Mukae H. The Novel Arylamidine T-2307 Selectively Disrupts Yeast Mitochondrial Function by Inhibiting Respiratory Chain Complexes. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00374-19. doi: 10.1128/AAC.00374-19. PMID: 31182539; PMCID: PMC6658782.
4: Wiederhold NP, Najvar LK, Jaramillo R, Olivo M, Patterson H, Connell A, Fukuda Y, Mitsuyama J, Catano G, Patterson TF. The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity against Candida auris. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02198-19. doi: 10.1128/AAC.02198-19. PMID: 31844006; PMCID: PMC7038306.
5: Nishikawa H, Sakagami T, Yamada E, Fukuda Y, Hayakawa H, Nomura N, Mitsuyama J, Miyazaki T, Mukae H, Kohno S. T-2307, a novel arylamidine, is transported into Candida albicans by a high-affinity spermine and spermidine carrier regulated by Agp2. J Antimicrob Chemother. 2016 Jul;71(7):1845-55. doi: 10.1093/jac/dkw095. Epub 2016 Apr 18. PMID: 27090633.
6: Shibata T, Takahashi T, Yamada E, Kimura A, Nishikawa H, Hayakawa H, Nomura N, Mitsuyama J. T-2307 causes collapse of mitochondrial membrane potential in yeast. Antimicrob Agents Chemother. 2012 Nov;56(11):5892-7. doi: 10.1128/AAC.05954-11. Epub 2012 Sep 4. PMID: 22948882; PMCID: PMC3486560.
7: Wiederhold NP, Najvar LK, Fothergill AW, Bocanegra R, Olivo M, McCarthy DI, Fukuda Y, Mitsuyama J, Patterson TF. The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata. J Antimicrob Chemother. 2016 Mar;71(3):692-5. doi: 10.1093/jac/dkv398. Epub 2015 Nov 29. PMID: 26620102; PMCID: PMC4743701.
8: Nishikawa H, Yamada E, Shibata T, Uchihashi S, Fan H, Hayakawa H, Nomura N, Mitsuyama J. Uptake of T-2307, a novel arylamidine, in Candida albicans. J Antimicrob Chemother. 2010 Aug;65(8):1681-7. doi: 10.1093/jac/dkq177. Epub 2010 May 30. PMID: 20513704.
9: Yamada E, Nishikawa H, Nomura N, Mitsuyama J. T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. Antimicrob Agents Chemother. 2010 Sep;54(9):3630-4. doi: 10.1128/AAC.00355-10. Epub 2010 Jun 14. PMID: 20547803; PMCID: PMC2935006.
10: Nishikawa H, Fukuda Y, Mitsuyama J, Tashiro M, Tanaka A, Takazono T, Saijo T, Yamamoto K, Nakamura S, Imamura Y, Miyazaki T, Kakeya H, Yamamoto Y, Yanagihara K, Mukae H, Kohno S, Izumikawa K. In vitro and in vivo antifungal activities of T-2307, a novel arylamidine, against Cryptococcus gattii: an emerging fungal pathogen. J Antimicrob Chemother. 2017 Jun 1;72(6):1709-1713. doi: 10.1093/jac/dkx020. PMID: 28201509; PMCID: PMC5890668.
