Procarbazine HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 100760

CAS#: 366-70-1 (HCl)

Description: Procarbazine is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as glioblastoma multiforme). It is a member of a group of medicines called alkylating agents. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine. It gained FDA Approved in July 1969. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Chemical Structure

Procarbazine HCl
CAS# 366-70-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 100760
Name: Procarbazine HCl
CAS#: 366-70-1 (HCl)
Chemical Formula: C12H20ClN3O
Exact Mass: 221.15281
Molecular Weight: 257.762
Elemental Analysis: C, 55.92; H, 7.82; Cl, 13.75; N, 16.30; O, 6.21

Size Price Shipping out time Quantity
50mg USD 150 Same day
1g USD 250 Same day
2g USD 350 Same day
5g USD 550 Same day
10g USD 950 Same day
20g USD 1650 Same day
100g USD 3650 Same day
500g USD 8950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

Procarbazine HCl, purity > 98%, is in stock. The same day shipping after order received

Related CAS #: 671-16-9 (free base)   366-70-1 (HCl)   18969-59-0 (HBr)    

Synonym: CB 400-497; NSC-77213; Ro 4-6467; Ro 4-6467/1; Procarbazine Hydrochloride; PCB Hydrochloride; PCZ; Procarbazin. Matulane. Natulan; Natulanar; Natunalar.

IUPAC/Chemical Name: N-isopropyl-4-((2-methylhydrazinyl)methyl)benzamide hydrochloride


InChi Code: InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H


Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Preparing Stock Solutions

The following data is based on the product molecular weight 257.762 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

  1: Yap KY, Tay WL, Chui WK, Chan A. Clinically relevant drug interactions between anticancer drugs and psychotropic agents. Eur J Cancer Care (Engl). 2009 Dec 17. [Epub ahead of print] PubMed PMID: 20030690.

2: Roos WP, Nikolova T, Quiros S, Naumann SC, Kiedron O, Zdzienicka MZ, Kaina B. Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs. DNA Repair (Amst). 2009 Jan 1;8(1):72-86. Epub 2008 Oct 21. PubMed PMID: 18840549.

3: Ribrag V, Koscielny S, Casasnovas O, Cazeneuve C, Brice P, Morschhauser F, Gabarre J, Stamatoullas A, Lenoir G, Salles G; Groupe d'Etude des Lymphomes agressifs group, Laboratoire de Génétique et de recherche translationnelle, and Institut Gustave Roussy. Pharmacogenetic study in Hodgkin lymphomas reveals the impact of UGT1A1 polymorphisms on patient prognosis. Blood. 2009 Apr 2;113(14):3307-13. Epub 2008 Sep 3. PubMed PMID: 18768784.

4: Krawczuk-Rybak M, Leszczyńska E, Wysocka J, Zelazowska-Rutkowska B. [Anti-mullerian hormone in young women after chemotherapy and infradiaphragmatic radiotherapy for childhood cancer]. Pediatr Endocrinol Diabetes Metab. 2008;14(2):99-103. Polish. PubMed PMID: 18721496.

5: Glen CD, Smith AG, Dubrova YE. Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice. Cancer Res. 2008 May 15;68(10):3630-6. PubMed PMID: 18483245.

6: Gasowska-Bajger B, Wojtasek H. Indirect oxidation of the antitumor agent procarbazine by tyrosinase--possible application in designing anti-melanoma prodrugs. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3296-300. Epub 2008 Apr 22. PubMed PMID: 18457951.

7: Armand JP, Ribrag V, Harrousseau JL, Abrey L. Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. Ther Clin Risk Manag. 2007 Jun;3(2):213-24. PubMed PMID: 18360630; PubMed Central PMCID: PMC1936303.

8: Grossman SA, Carson KA, Batchelor TT, Lesser G, Mikkelsen T, Alavi JB, Phuphanich S, Hammour T, Fisher JD, Supko JG. The effect of enzyme-inducing antiseizure drugs on the pharmacokinetics and tolerability of procarbazine hydrochloride. Clin Cancer Res. 2006 Sep 1;12(17):5174-81. PubMed PMID: 16951236.

9: Giordana MT, Ghimenti C, Leonardo E, Balteri I, Iudicello M, Duò D. Molecular genetic study of a metastatic oligodendroglioma. J Neurooncol. 2004 Feb;66(3):265-71. PubMed PMID: 15015656.

10: Ewesuedo RB, Dolan ME. Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat. Cancer Chemother Pharmacol. 2000;46(2):150-5. PubMed PMID: 10972485.