WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 112148
CAS#: 1012327-63-7
Description: PX-866-17OH inhibits PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively).
MedKoo Cat#: 112148
Name: PX-866-17OH
CAS#: 1012327-63-7
Chemical Formula: C29H37NO8
Exact Mass: 527.2519
Molecular Weight: 527.61
Elemental Analysis: C, 66.02; H, 7.07; N, 2.65; O, 24.26
Synonym: PX-866-17OH
IUPAC/Chemical Name: (4S,4aR,5R,6aS,7S,9aR,E)-1-((diallylamino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
InChi Key: STKVQJOXRFVEDM-DATHZOKXSA-N
InChi Code: InChI=1S/C29H37NO8/c1-7-11-30(12-8-2)14-17-23-26(34)25(33)22-18-9-10-20(32)28(18,4)13-19(37-16(3)31)24(22)29(23,5)21(15-36-6)38-27(17)35/h7-8,14,18-21,32,34H,1-2,9-13,15H2,3-6H3/b17-14+/t18-,19+,20-,21+,28-,29-/m0/s1
SMILES Code: O=C(O[C@@H]([C@]1(C/2=C(C(C3=C1[C@@H](C[C@]4([C@]3(CC[C@@H]4O)[H])C)OC(C)=O)=O)O)C)COC)C2=C\N(CC=C)CC=C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 527.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
