WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 466280
CAS#: unknown
Description: Pyrifazimine, also known as TBI-166, is a Tuberculosis candidate.
MedKoo Cat#: 466280
Name: Pyrifazimine
CAS#: unknown
Chemical Formula: C32H30F3N5O3
Exact Mass: 589.2301
Molecular Weight: 589.6192
Elemental Analysis: C, 65.19; H, 5.13; F, 9.67; N, 11.88; O, 8.14
This product is not in stock, which may be available by custom synthesis.
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Synonym: Pyrifazimine; TBI-166; TBI 166; TBI166;
IUPAC/Chemical Name: (E)-3-((4-methoxycyclohexyl)imino)-N-(2-methoxypyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-3,5-dihydrophenazin-2-amine
InChi Key: GUSGYHIQYWRCQO-NXEFEZKASA-N
InChi Code: InChI=1S/C32H30F3N5O3/c1-41-22-13-9-20(10-14-22)37-27-19-30-28(18-26(27)39-25-7-5-17-36-31(25)42-2)38-24-6-3-4-8-29(24)40(30)21-11-15-23(16-12-21)43-32(33,34)35/h3-8,11-12,15-20,22,39H,9-10,13-14H2,1-2H3/b37-27+
SMILES Code: COC(CC1)CCC1/N=C2C(NC3=C(OC)N=CC=C3)=CC4=NC5=CC=CC=C5N(C6=CC=C(OC(F)(F)F)C=C6)C4=C/2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 589.6192 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Liu HT, Fu L, Wang B, Wang N, Li DS, Ding YM, Yao R, Qi XT, Lu Y. [Study on the pharmacodynamic activity of combinations with the new anti-tuberculosis drug pyrifazimine in vitro and in vivo in mouse]. Zhonghua Jie He He Hu Xi Za Zhi. 2022 Jun 12;45(6):560-566. Chinese. doi: 10.3760/cma.j.cn112147-20211008-00697. PMID: 35658380.
