Lomustine
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MedKoo CAT#: 100550

CAS#: 13010-47-4

Description: Lomustine is a nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).


Chemical Structure

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Lomustine
CAS# 13010-47-4

Theoretical Analysis

MedKoo Cat#: 100550
Name: Lomustine
CAS#: 13010-47-4
Chemical Formula: C9H16ClN3O2
Exact Mass: 233.0931
Molecular Weight: 233.69524
Elemental Analysis: C, 46.26; H, 6.90; Cl, 15.17; N, 17.98; O, 13.69

Price and Availability

Size Price Availability Quantity
50.0mg USD 190.0 Same day
1.0g USD 250.0 Same day
5.0g USD 450.0 Same day
10.0g USD 750.0 Same day
50.0g USD 2250.0 Same day
100.0g USD 3450.0 Same day
1.0kg USD 6950.0 2 Weeks
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Synonym: Lomustinume. CeeNU; Belustin; Belustine; Cecenu; Citostal; Lomeblastin; Lucostin; Lucostine; Prava. CCNU. Acronym: CCNU. RB1509; WR139017.

IUPAC/Chemical Name: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

InChi Key: GQYIWUVLTXOXAJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

SMILES Code: O=C(NC1CCCCC1)N(CCCl)N=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under cool temperature as non-hazardous chemical.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 233.69524 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information