Levamisole hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 100540

CAS#: 16595-80-5 (HCl)

Description: Levamisole hydrochloride is the orally bioavailable hydrochloride salt of the synthetic imidazothiazole derivative levamisole with anthelminthic and immunostimulating activities. In immunosuppressed states, levamisole may restore immune function by: 1) stimulating antibody formation, 2) stimulating T-cell activation and proliferation, 3) potentiatiating monocyte and macrophage phagocytosis and chemotaxis and 4) increasing neutrophil mobility, adherence, and chemotaxis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Chemical Structure

Levamisole hydrochloride
CAS# 16595-80-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 100540
Name: Levamisole hydrochloride
CAS#: 16595-80-5 (HCl)
Chemical Formula: C11H12N2S
Exact Mass: 204.07212
Molecular Weight: 204.29
Elemental Analysis: C, 64.67; H, 5.92; N, 13.71; S, 15.70

Price and Availability

Size Price Availability Quantity
10.0g USD 210.0 2 Weeks
25.0g USD 360.0 2 Weeks
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Related CAS #: 14769-73-4 (free base)   16595-80-5 (HCl)   32093-35-9 (phosphate)    

Synonym: ltetramisole hydrochloride; US brand name: Ergamisol. Foreign brand names: Ascaridil; Decaris; Ergamisole; Ketrax; Solaskil. Abbreviation: LEV. Code names: ICI59623; R 12564; RP20605.

IUPAC/Chemical Name: (S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride


InChi Code: InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1

SMILES Code: [H]Cl.C12=N[C@@H](C3=CC=CC=C3)CN1CCS2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 204.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information

 According to http://en.wikipedia.org/wiki/Levamisole, Levamisole (marketed as the hydrochloride salt under the trade name Ergamisol) is an anthelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. It was discovered at Janssen Pharmaceutica in 1966. Levamisole has been used in humans to treat parasitic worm infections, and has been studied in combination with other forms of chemotherapy for colon cancer, melanoma, and head and neck cancer. The drug was withdrawn from the U.S. and Canadian markets in 2000 and 2003 respectively, due to the risk of serious side effects and the availability of more effective replacement medications. Currently, levamisole remains in veterinary use as a dewormer for livestock. The medication has also been increasingly used as an adulterant in cocaine sold in the US and Canada, resulting in serious side effects.