Goserelin Acetate
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 100420

CAS#: 145781-92-6 (acetate)

Description: Goserelin is a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH) with antineoplastic activity. Goserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of this agent in a depot formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function.


Chemical Structure

img
Goserelin Acetate
CAS# 145781-92-6 (acetate)

Theoretical Analysis

MedKoo Cat#: 100420
Name: Goserelin Acetate
CAS#: 145781-92-6 (acetate)
Chemical Formula: C61H88N18O16
Exact Mass:
Molecular Weight: 1329.485
Elemental Analysis: C, 55.11; H, 6.67; N, 18.96; O, 19.25

Price and Availability

Size Price Availability Quantity
25.0mg USD 175.0 Same day
50.0mg USD 320.0 Same day
100.0mg USD 520.0 Same day
200.0mg USD 936.0 Same day
500.0mg USD 2106.0 Same day
1.0g USD 3550.0 2 weeks
2.0g USD 5850.0 2 weeks
5.0g USD 12950.0 2 weeks
Click to view more sizes and prices
Bulk inquiry

Related CAS #: 65807-02-5 (free base)   145781-92-6 (acetate)    

Synonym: ICI118630; ICI-118630; ICI 118630; Goserelin Acetate; brand name: Zoladex.

IUPAC/Chemical Name: (S)-N-((6S,9S,12R,15S,18S,21S,24S)-21-((1H-indol-3-yl)methyl)-1-amino-12-(tert-butoxymethyl)-6-((S)-2-(2-carbamoylhydrazine-1-carbonyl)pyrrolidine-1-carbonyl)-15-(4-hydroxybenzyl)-18-(hydroxymethyl)-25-(1H-imidazol-4-yl)-1-imino-9-isobutyl-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazapentacosan-24-yl)-5-oxopyrrolidine-2-carboxamide acetate

InChi Key: IKDXDQDKCZPQSZ-JHYYTBFNSA-N

InChi Code: InChI=1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1

SMILES Code: OC(C)=O.NC(NCCC[C@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC=N1)NC([C@@H]2CCC(N2)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)CO)=O)CC5=CC=C(C=C5)O)=O)COC(C)(C)C)=O)CC(C)C)=O)C(N6CCC[C@H]6C(NNC(N)=O)=O)=O)=N

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO and in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 1329.485 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Roach M 3rd, Izaguirre A. Goserelin acetate in combination with radiotherapy for prostate cancer. Expert Opin Pharmacother. 2007 Feb;8(2):257-64. Review. PubMed PMID: 17257094.

2: Tsukagoshi S. [A new LH-RH agonist for treatment of prostate cancer, 3-month controlled-release formulation of goserelin acetate (Zoladex LA 10.8 mg depot)--outline of pre-clinical and clinical studies]. Gan To Kagaku Ryoho. 2002 Sep;29(9):1675-87. Review. Japanese. PubMed PMID: 12355959.

3: Koga H, Naito S. [Goserelin acetate depot, LH-RH agonist; its properties and therapeutic effects in prostate cancer]. Nihon Rinsho. 2000 Jul;58 Suppl:186-90. Review. Japanese. PubMed PMID: 11022711.

4: Goldspiel BR, Kohler DR. Goserelin acetate implant: a depot luteinizing hormone-releasing hormone analog for advanced prostate cancer. DICP. 1991 Jul-Aug;25(7-8):796-804. Review. PubMed PMID: 1835221.



Additional Information

 Goserelin (free base)
Chemical Formula: C59H84N18O14
Exact Mass: 1268.6414
Molecular Weight: 1269.4330
Elemental Analysis: C, 55.82; H, 6.67; N, 19.86; O, 17.64