Goserelin Acetate
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MedKoo CAT#: 100420

CAS#: 145781-92-6 (acetate)

Description: Goserelin is a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH) with antineoplastic activity. Goserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of this agent in a depot formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function.


Chemical Structure

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Goserelin Acetate
CAS# 145781-92-6 (acetate)

Theoretical Analysis

MedKoo Cat#: 100420
Name: Goserelin Acetate
CAS#: 145781-92-6 (acetate)
Chemical Formula: C61H88N18O16
Exact Mass:
Molecular Weight: 1329.485
Elemental Analysis: C, 55.11; H, 6.67; N, 18.96; O, 19.25

Size Price Shipping out time Quantity
25mg USD 175 Same day
50mg USD 320 Same day
100mg USD 520 Same day
200mg USD 936 Same day
500mg USD 2106 Same day
1g USD 3550 2 weeks
2g USD 5850 2 weeks
5g USD 12950 2 weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-03. Prices are subject to change without notice.

Goserelin Acetate, purity > 98%, is in stock. The same day shipping out after order is received.

Related CAS #: 65807-02-5 (free base)   145781-92-6 (acetate)    

Synonym: ICI118630; ICI-118630; ICI 118630; Goserelin Acetate; brand name: Zoladex.

IUPAC/Chemical Name: (S)-N-((6S,9S,12R,15S,18S,21S,24S)-21-((1H-indol-3-yl)methyl)-1-amino-12-(tert-butoxymethyl)-6-((S)-2-(2-carbamoylhydrazine-1-carbonyl)pyrrolidine-1-carbonyl)-15-(4-hydroxybenzyl)-18-(hydroxymethyl)-25-(1H-imidazol-4-yl)-1-imino-9-isobutyl-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazapentacosan-24-yl)-5-oxopyrrolidine-2-carboxamide acetate

InChi Key: IKDXDQDKCZPQSZ-JHYYTBFNSA-N

InChi Code: InChI=1S/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1

SMILES Code: OC(C)=O.NC(NCCC[C@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC=N1)NC([C@@H]2CCC(N2)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)CO)=O)CC5=CC=C(C=C5)O)=O)COC(C)(C)C)=O)CC(C)C)=O)C(N6CCC[C@H]6C(NNC(N)=O)=O)=O)=N

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO and in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 1329.485 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Roach M 3rd, Izaguirre A. Goserelin acetate in combination with radiotherapy for prostate cancer. Expert Opin Pharmacother. 2007 Feb;8(2):257-64. Review. PubMed PMID: 17257094.

2: Tsukagoshi S. [A new LH-RH agonist for treatment of prostate cancer, 3-month controlled-release formulation of goserelin acetate (Zoladex LA 10.8 mg depot)--outline of pre-clinical and clinical studies]. Gan To Kagaku Ryoho. 2002 Sep;29(9):1675-87. Review. Japanese. PubMed PMID: 12355959.

3: Koga H, Naito S. [Goserelin acetate depot, LH-RH agonist; its properties and therapeutic effects in prostate cancer]. Nihon Rinsho. 2000 Jul;58 Suppl:186-90. Review. Japanese. PubMed PMID: 11022711.

4: Goldspiel BR, Kohler DR. Goserelin acetate implant: a depot luteinizing hormone-releasing hormone analog for advanced prostate cancer. DICP. 1991 Jul-Aug;25(7-8):796-804. Review. PubMed PMID: 1835221.



Additional Information

 Goserelin (free base)
Chemical Formula: C59H84N18O14
Exact Mass: 1268.6414
Molecular Weight: 1269.4330
Elemental Analysis: C, 55.82; H, 6.67; N, 19.86; O, 17.64