Diaziquone

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MedKoo CAT#: 100265

CAS#: 57998-68-2

Description: Diaziquone is a synthetic bifunctional quinone derivative with potential antineoplastic activity. Diaziquone alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent can also form free radicals, thereby initiating DNA damage via DNA strand breaks. Due to its lipophilicity, diaziquone readily crosses the blood brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).


Chemical Structure

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Diaziquone
CAS# 57998-68-2

Theoretical Analysis

MedKoo Cat#: 100265
Name: Diaziquone
CAS#: 57998-68-2
Chemical Formula: C16H20N4O6
Exact Mass: 364.13828
Molecular Weight: 364.35
Elemental Analysis: C, 52.74; H, 5.53; N, 15.38; O, 26.35

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Synonym: Aziridinyl Benzoquinone; aziridinylbenzoquinone; Aziridinylbenzoquinone carbamic acid. Abbreviation: AZQ. Code name: CI904.

IUPAC/Chemical Name: diethyl (2,5-di(aziridin-1-yl)-3,6-dioxocyclohexa-1,4-diene-1,4-diyl)dicarbamate

InChi Key: WVYXNIXAMZOZFK-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H20N4O6/c1-3-25-15(23)17-9-11(19-5-6-19)14(22)10(18-16(24)26-4-2)12(13(9)21)20-7-8-20/h3-8H2,1-2H3,(H,17,23)(H,18,24)

SMILES Code: O=C(C(NC(OCC)=O)=C1N2CC2)C(N3CC3)=C(NC(OCC)=O)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 364.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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