Cyclophosphamide monohydrate
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MedKoo CAT#: 100190

CAS#: 6055-19-2 (hydrate)

Description: Cyclophosphamide, also known as cytophosphane among other, is used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome and following organ transplant. It is taken by mouth or injection into a vein. The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low levels of ALDH. Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastrand crosslinkages, respectively). This is irreversible and leads to cell apoptosis.


Chemical Structure

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Cyclophosphamide monohydrate
CAS# 6055-19-2 (hydrate)

Theoretical Analysis

MedKoo Cat#: 100190
Name: Cyclophosphamide monohydrate
CAS#: 6055-19-2 (hydrate)
Chemical Formula: C7H15Cl2N2O2P
Exact Mass:
Molecular Weight: 279.10124
Elemental Analysis: C, 32.20; H, 5.79; Cl, 27.16; N, 10.73; O, 12.26; P, 11.86

Size Price Shipping out time Quantity
2g USD 150 Same day
5g USD 250 Same day
10g USD 450 Same day
25g USD 650 2 weeks
50g USD 950 2 weeks
100g USD 1750 2 weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-03. Prices are subject to change without notice.

Cyclophosphamide Monohydrate, purity > 98%, is in stock.

Related CAS #: 6055-19-2 (hydrate)   50-18-0 (anhydrous)    

Synonym: Ciclofosfamida; Ciclofosfamide; Cyclophosphamide monohydrate.

IUPAC/Chemical Name: 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate

InChi Key: PWOQRKCAHTVFLB-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

SMILES Code: ClCCN(P1(OCCCN1)=O)CCCl.[H]O[H]

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 279.10124 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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7: Miki T, Mizutani Y, Akaza H, Ozono S, Tsukamoto T, Terachi T, Naito K, Nonomura N, Hara I, Yoshida O; Japan Blood Cell Transplantation Study Group for Testicular Germ Cell Tumor. Long-term results of first-line sequential high-dose carboplatin, etoposide and ifosfamide chemotherapy with peripheral blood stem cell support for patients with advanced testicular germ cell tumor. Int J Urol. 2007 Jan;14(1):54-9. PubMed PMID: 17199861.

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Additional Information

Related CAS#
6055-19-2 (Cyclophosphamide hydrate);
50-18-0 (Cyclophosphamide anhydrous)