WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 100136
Description: Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.
MedKoo Cat#: 100136
Chemical Formula: C11H16FN3O3
Exact Mass: 257.11757
Molecular Weight: 257.26144
Elemental Analysis: C, 51.36; H, 6.27; F, 7.38; N, 16.33; O, 18.66
Carmofur purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 200mg may be 2 weeks.
Synonym: HCFU; 1hexylcarbamoyl5fluorouracil.
IUPAC/Chemical Name: 5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide
InChi Key: AOCCBINRVIKJHY-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
SMILES Code: O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
The following data is based on the product molecular weight 257.26144 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Pizzirani D, Pagliuca C, Realini N, Branduardi D, Bottegoni G, Mor M, Bertozzi F, Scarpelli R, Piomelli D, Bandiera T. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem. 2013 May 9;56(9):3518-30. doi: 10.1021/jm301879g. Epub 2013 Apr 24. PubMed PMID: 23614460.
2: Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep. 2013;3:1035. doi: 10.1038/srep01035. Epub 2013 Jan 8. PubMed PMID: 23301156; PubMed Central PMCID: PMC3539145.
3: Hermunen K, Haglund C, Osterlund P. CEA fluctuation during a single fluorouracil-based chemotherapy cycle for metastatic colorectal cancer. Anticancer Res. 2013 Jan;33(1):253-60. PubMed PMID: 23267153.
4: Song XQ, Guo YL, Wang BG, Sun SJ, Yao RY. [Effect of tagalsin on p53 and Bcl-2 expression in hepatoma H(22) tumor-bearing mice]. Zhonghua Zhong Liu Za Zhi. 2011 Jul;33(7):499-503. Chinese. PubMed PMID: 22093625.
5: Verma AK, Chanchal A, Maitra A. Co-polymeric hydrophilic nanospheres for drug delivery: release kinetics, and cellular uptake. Indian J Exp Biol. 2010 Oct;48(10):1043-52. PubMed PMID: 21299047.
6: Yamamoto H, Hemmi H, Gu JY, Sekimoto M, Doki Y, Mori M. Minute liver metastases from a rectal carcinoid: A case report and review. World J Gastrointest Surg. 2010 Mar 27;2(3):89-94. doi: 10.4240/wjgs.v2.i3.89. PubMed PMID: 21160856; PubMed Central PMCID: PMC2999217.
7: Miyazaki N, Tabata Y. Anti-tumor activity of carmofur water-solubilized by lactic acid oligomer-grafted pullulan nanogels. J Nanosci Nanotechnol. 2009 Aug;9(8):4797-804. PubMed PMID: 19928152.
8: Wang S, Liu Q, Zhang Y, Liu K, Yu P, Liu K, Luan J, Duan H, Lu Z, Wang F, Wu E, Yagasaki K, Zhang G. Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer. 2009 Oct 1;8:81. doi: 10.1186/1476-4598-8-81. PubMed PMID: 19796390; PubMed Central PMCID: PMC2765940.
9: Samuel M, Chow PK, Chan Shih-Yen E, Machin D, Soo KC. Neoadjuvant and adjuvant therapy for surgical resection of hepatocellular carcinoma. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001199. doi: 10.1002/14651858.CD001199.pub2. Review. PubMed PMID: 19160192.
10: Sakai T, Yamashita Y, Maekawa T, Mikami K, Hoshino S, Shirakusa T. Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer. Cancer Biother Radiopharm. 2008 Aug;23(4):461-7. doi: 10.1089/cbr.2008.0484. PubMed PMID: 18771350.
Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil. Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.