QPX7831 Sodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 208008

CAS#: N/A

Description: Novel Orally Bioavailable Prodrug of Boronic Acid β-Lactamase Inhibitor QPX7728 (GLXC-22429)

Chemical Structure

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QPX7831 Sodium
CAS# N/A
Instruction

Theoretical Analysis

MedKoo Cat#: 208008
Name: QPX7831 Sodium
CAS#: N/A
Chemical Formula: C15H15BFNaO6
Exact Mass: 344.08
Molecular Weight: 344.077
Elemental Analysis: C, 52.36; H, 4.39; B, 3.14; F, 5.52; Na, 6.68; O, 27.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: QPX7831 Sodium; QPX7831Sodium

IUPAC/Chemical Name: Sodium (1aR,7bS)-5-fluoro-4-(((isobutyryloxy)methoxy)carbonyl)-1a,7b-dihydrobenzo[e]cyclopropa[c][1,2]oxaborinin-2(1H)-olate

InChi Key: YFLAXRHSCNOJBN-DHTOPLTISA-N

InChi Code: InChI=1S/C15H15BFO6.Na/c1-7(2)14(18)21-6-22-15(19)12-11(17)4-3-8-9-5-10(9)16(20)23-13(8)12;/h3-4,7,9-10H,5-6H2,1-2H3;/q-1;+1/t9-,10-;/m1./s1

SMILES Code: CC(C)C(OCOC(C1=C(OB(O[Na])[C@@H]2C[C@@H]23)C3=CC=C1F)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 344.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Reddy KR, Parkinson J, Sabet M, Tarazi Z, Boyer SH, Lomovskaya O, Griffith DC, Hecker SJ, Dudley MN. Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid β-Lactamase Inhibitor QPX7728. J Med Chem. 2021 Dec 9;64(23):17523-17529. doi: 10.1021/acs.jmedchem.1c01722. Epub 2021 Nov 24. PMID: 34817182.