WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510340
CAS#: 219766-25-3
Description: ANA-12 is aTrkB receptor antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Systemic administration of ANA-12 to adult mice decreased TrkB activity in the brain without affecting neuronal survival. Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans. ANA-12 may be a valuable tool for studying BDNF/TrkB signaling and may constitute a lead compound for developing the next generation of therapeutic agents for the treatment of mood disorders.
MedKoo Cat#: 510340
Name: ANA-12
CAS#: 219766-25-3
Chemical Formula: C22H21N3O3S
Exact Mass: 407.13036
Molecular Weight: 407.49
Elemental Analysis: C, 64.85; H, 5.19; N, 10.31; O, 11.78; S, 7.87
Synonym: ANA12; ANA 12; ANA-12.
IUPAC/Chemical Name: N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide
InChi Key: TUSCYCAIGRVBMD-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26)
SMILES Code: O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 407.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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6: Li PC, Jiao Y, Ding J, Chen YC, Cui Y, Qian C, Yang XY, Ju SH, Yao HH, Teng GJ. Cystamine Improves Functional Recovery via Axon Remodeling and Neuroprotection after Stroke in Mice. CNS Neurosci Ther. 2015 Mar;21(3):231-40. doi: 10.1111/cns.12343. Epub 2014 Nov 27. PubMed PMID: 25430473.
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8: Chen W, Walwyn W, Ennes HS, Kim H, McRoberts JA, Marvizón JC. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci. 2014 May;39(9):1439-54. doi: 10.1111/ejn.12516. Epub 2014 Mar 11. PubMed PMID: 24611998; PubMed Central PMCID: PMC4122572.
9: Leggio GM, Camillieri G, Platania CB, Castorina A, Marrazzo G, Torrisi SA, Nona CN, D'Agata V, Nobrega J, Stark H, Bucolo C, Le Foll B, Drago F, Salomone S. Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone. Neuropsychopharmacology. 2014 Jul;39(8):2017-28. doi: 10.1038/npp.2014.51. Epub 2014 Mar 3. PubMed PMID: 24584330; PubMed Central PMCID: PMC4059912.
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