ANA-12
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MedKoo CAT#: 510340

CAS#: 219766-25-3

Description: ANA-12 is aTrkB receptor antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Systemic administration of ANA-12 to adult mice decreased TrkB activity in the brain without affecting neuronal survival. Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans. ANA-12 may be a valuable tool for studying BDNF/TrkB signaling and may constitute a lead compound for developing the next generation of therapeutic agents for the treatment of mood disorders.


Chemical Structure

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ANA-12
CAS# 219766-25-3

Theoretical Analysis

MedKoo Cat#: 510340
Name: ANA-12
CAS#: 219766-25-3
Chemical Formula: C22H21N3O3S
Exact Mass: 407.13036
Molecular Weight: 407.49
Elemental Analysis: C, 64.85; H, 5.19; N, 10.31; O, 11.78; S, 7.87

Price and Availability

Size Price Availability Quantity
10.0mg USD 150.0 Same Day
25.0mg USD 250.0 Same Day
50.0mg USD 450.0 Same Day
100.0mg USD 650.0 Same Day
200.0mg USD 950.0 Same Day
500.0mg USD 1650.0 Same Day
1.0g USD 2250.0 2 Weeks
2.0g USD 3950.0 2 Weeks
5.0g USD 5950.0 2 Weeks
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Synonym: ANA12; ANA 12; ANA-12.

IUPAC/Chemical Name: N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide

InChi Key: TUSCYCAIGRVBMD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26)

SMILES Code: O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 407.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Tillu DV, Hassler SN, Burgos-Vega CC, Quinn TL, Sorge RE, Dussor G, Boitano S, Vagner J, Price TJ. Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state. Pain. 2015 Feb 12. [Epub ahead of print] PubMed PMID: 25734998.

2: Dalton JE, Glover AC, Hoodless L, Lim EK, Beattie L, Kirby A, Kaye PM. The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection. PLoS Pathog. 2015 Feb 24;11(2):e1004681. doi: 10.1371/journal.ppat.1004681. eCollection 2015 Feb. PubMed PMID: 25710496; PubMed Central PMCID: PMC4339582.

3: Zhang JC, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li SX, Shirayama Y, Hashimoto K. Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation. Int J Neuropsychopharmacol. 2014 Oct 31;18(4). pii: pyu077. doi: 10.1093/ijnp/pyu077. PubMed PMID: 25628381.

4: Kishi T, Hirooka Y, Nagayama T, Isegawa K, Katsuki M, Takesue K, Sunagawa K. Calorie Restriction Improves Cognitive Decline via Up-Regulation of Brain-Derived Neurotrophic Factor. Int Heart J. 2015 Jan 21;56(1):110-5. doi: 10.1536/ihj.14-168. Epub 2014 Dec 11. PubMed PMID: 25503654.

5: Fan D, Li J, Zheng B, Hua L, Zuo Z. Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression. Mol Neurobiol. 2014 Nov 29. [Epub ahead of print] PubMed PMID: 25432890.

6: Li PC, Jiao Y, Ding J, Chen YC, Cui Y, Qian C, Yang XY, Ju SH, Yao HH, Teng GJ. Cystamine Improves Functional Recovery via Axon Remodeling and Neuroprotection after Stroke in Mice. CNS Neurosci Ther. 2015 Mar;21(3):231-40. doi: 10.1111/cns.12343. Epub 2014 Nov 27. PubMed PMID: 25430473.

7: Liang DY, Sun Y, Shi XY, Sahbaie P, Clark JD. Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia. Mol Pain. 2014 Sep 12;10:59. doi: 10.1186/1744-8069-10-59. PubMed PMID: 25217253; PubMed Central PMCID: PMC4171542.

8: Chen W, Walwyn W, Ennes HS, Kim H, McRoberts JA, Marvizón JC. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci. 2014 May;39(9):1439-54. doi: 10.1111/ejn.12516. Epub 2014 Mar 11. PubMed PMID: 24611998; PubMed Central PMCID: PMC4122572.

9: Leggio GM, Camillieri G, Platania CB, Castorina A, Marrazzo G, Torrisi SA, Nona CN, D'Agata V, Nobrega J, Stark H, Bucolo C, Le Foll B, Drago F, Salomone S. Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone. Neuropsychopharmacology. 2014 Jul;39(8):2017-28. doi: 10.1038/npp.2014.51. Epub 2014 Mar 3. PubMed PMID: 24584330; PubMed Central PMCID: PMC4059912.

10: Greenberg GD, Laman-Maharg A, Campi KL, Voigt H, Orr VN, Schaal L, Trainor BC. Sex differences in stress-induced social withdrawal: role of brain derived neurotrophic factor in the bed nucleus of the stria terminalis. Front Behav Neurosci. 2014 Jan 9;7:223. doi: 10.3389/fnbeh.2013.00223. eCollection 2014. PubMed PMID: 24409132; PubMed Central PMCID: PMC3885825.

ANA-12

10.0mg / USD 150.0


Additional Information