Acecainide

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MedKoo CAT#: 577980

CAS#: 32795-44-1

Description: Acecainide is the N-acetylated metabolite of Procainamide and a Class III anti-arrhythmic agent.


Chemical Structure

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Acecainide
CAS# 32795-44-1

Theoretical Analysis

MedKoo Cat#: 577980
Name: Acecainide
CAS#: 32795-44-1
Chemical Formula: C15H23N3O2
Exact Mass: 277.18
Molecular Weight: 277.370
Elemental Analysis: C, 64.96; H, 8.36; N, 15.15; O, 11.54

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Acecainide

IUPAC/Chemical Name: Acetanilide, 4'-((2-(diethylamino)ethyl)carbamoyl)-

InChi Key: KEECCEWTUVWFCV-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H23N3O2/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19)

SMILES Code: CCN(CC)CCNC(=O)c1ccc(NC(=O)C)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 277.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Harron DW, Brogden RN. Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiac arrhythmias. Drugs. 1990 May;39(5):720-40. Review. PubMed PMID: 1693889.

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5: Roden DM, Reele SB, Higgins SB, Wilkinson GR, Smith RF, Oates JA, Woosley RL. Antiarrhythmic efficacy, pharmacokinetics and safety of N-acetylprocainamide in human subjects: comparison with procainamide. Am J Cardiol. 1980 Sep;46(3):463-8. PubMed PMID: 6158263.

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8: Bateman DN. Pharmacokinetics and metabolism of the benzamides. Adv Biochem Psychopharmacol. 1982;35:143-62. Review. PubMed PMID: 6183928.

9: Somberg J, Wynn J, Miura D, Torres V, Williams S, Keefe D. N-acetylprocainamide's antiarrhythmic action in patients with ventricular tachycardia. Angiology. 1986 Dec;37(12 Pt 2):972-81. PubMed PMID: 2433972.

10: Somogyi A, Heinzow B. Cimetidine reduces procainamide elimination. N Engl J Med. 1982 Oct 21;307(17):1080. PubMed PMID: 6181402.

11: Atkinson AJ Jr, Lertora JJ, Kushner W, Chao GC, Nevin MJ. Efficacy and safety of N-acetylprocainamide in long-term treatment of ventricular arrhythmias. Clin Pharmacol Ther. 1983 May;33(5):565-76. PubMed PMID: 6188570.

12: Liu XQ, Huang SK. [Combined pharmacokinetic and pharmacodynamic model analysis for procainamide and its metabolite]. Zhongguo Yao Li Xue Bao. 1991 Jan;12(1):7-11. Chinese. PubMed PMID: 1719744.

13: Kabra PM, Chen SH, Marton LJ. Liquid-chromatographic determination of antidysrhythmic drugs: procainamide, lidocaine, quinidine, disopyramide, and propranolol. Ther Drug Monit. 1981;3(1):91-101. PubMed PMID: 7233493.

14: Meisner DJ, Carlson RJ, Gottlieb AJ. Thrombocytopenia following sustained-release procainamide. Arch Intern Med. 1985 Apr;145(4):700-2. PubMed PMID: 2580499.

15: Pirovino M, Karlaganis G, Galeazzi RL. [Steady-state plasma and saliva concentrations of procainamide and N-acetyl-procainamide after a sustained release preparation]. Schweiz Med Wochenschr. 1980 Sep 27;110(39):1415-9. German. PubMed PMID: 6169144.

16: Karol MD, Goodrich S. Metabolite formation pharmacokinetics: rate and extent of metabolite formation determined by deconvolution. Pharm Res. 1988 Jun;5(6):347-51. PubMed PMID: 2469080.

17: Piergies AA, Ruo TI, Jansyn EM, Belknap SM, Atkinson AJ Jr. Effect kinetics of N-acetylprocainamide-induced QT interval prolongation. Clin Pharmacol Ther. 1987 Jul;42(1):107-12. PubMed PMID: 2439251.

18: Boucher M, Dubray C, Paire M, Duchêne-Marullaz P. Comparative effects of procainamide and its N-acetylated metabolite in conscious dogs with atrioventricular block: plasma concentration-response relationships. J Cardiovasc Pharmacol. 1987 Nov;10(5):562-7. PubMed PMID: 2447406.

19: Lahita R, Kluger J, Drayer DE, Koffler D, Reidenberg MM. Antibodies to nuclear antigens in patients treated with procainamide or acetylprocainamide. N Engl J Med. 1979 Dec 20;301(25):1382-5. PubMed PMID: 91972.

20: Ludden TM, Crawford MH, Kennedy GT. N-acetylprocainamide kinetics during intravenous infusions and subsequent oral doses in patients with coronary artery disease and ventricular arrhythmias. Pharmacotherapy. 1985 Jan-Feb;5(1):11-5. PubMed PMID: 2580291.