ONO-DI-004

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466172

CAS#: 250605-97-1

Description: ONO-DI-004 is a selective EP1 Prostanoid receptor agonist.


Chemical Structure

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ONO-DI-004
CAS# 250605-97-1

Theoretical Analysis

MedKoo Cat#: 466172
Name: ONO-DI-004
CAS#: 250605-97-1
Chemical Formula: C24H38O6
Exact Mass: 422.2668
Molecular Weight: 422.562
Elemental Analysis: C, 68.22; H, 9.06; O, 22.72

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ONO-DI-004; ONODI-004; ONO DI-004; ONO-DI004; ONO-DI 004; ONODI004; ONO DI 004;

IUPAC/Chemical Name: 4-(2-((1R,2R,3R)-3-hydroxy-2-((3S,5S,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)acetyl)cyclohexane-1-carboxylic acid

InChi Key: KWRRIFVHVJWXPU-HVCOQRSISA-N

InChi Code: InChI=1S/C24H38O6/c1-3-4-5-15(2)12-18(25)10-11-19-20(23(28)14-22(19)27)13-21(26)16-6-8-17(9-7-16)24(29)30/h10-11,15-20,22,25,27H,3-9,12-14H2,1-2H3,(H,29,30)/b11-10+/t15-,16?,17?,18+,19+,20+,22+/m0/s1

SMILES Code: O=C(C1CCC(C(C[C@@H]2[C@@H](/C=C/[C@H](C[C@@H](C)CCCC)O)[C@H](O)CC2=O)=O)CC1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 422.562 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nagano T, Tsuda N, Fujimura K, Ikezawa Y, Higashi Y, Kimura SH. Prostaglandin E2 increases the expression of cyclooxygenase-2 in cultured rat microglia. J Neuroimmunol. 2021 Dec 15;361:577724. doi: 10.1016/j.jneuroim.2021.577724. Epub 2021 Sep 23. PMID: 34610503.

2: Yang H, Wang M, Sun H, Zhu S, Jin J. Synergetic Effect of EP1 Receptor Antagonist and (-)-Epigallocatechin-3-gallate in Hepatocellular Carcinoma. Pharmacology. 2019;104(5-6):267-275. doi: 10.1159/000502076. Epub 2019 Aug 21. PMID: 31434088.

3: Reschke CR, Poersch AB, Masson CJ, Jesse AC, Marafiga JR, Lenz QF, Oliveira MS, Henshall DC, Mello CF. Systemic delivery of selective EP1 and EP3 receptor antagonists attenuates pentylenetetrazole-induced seizures in mice. Int J Physiol Pathophysiol Pharmacol. 2018 Mar 10;10(1):47-59. PMID: 29593850; PMCID: PMC5871629.

4: Nagano T, Nishiyama R, Sanada A, Mutaguchi Y, Ioku A, Umeki H, Kishimoto S, Yamanaka D, Kimura SH, Takemura M. Prostaglandin E2 potentiates interferon-γ-induced nitric oxide production in cultured rat microglia. J Neurochem. 2017 Feb;140(4):605-612. doi: 10.1111/jnc.13926. Epub 2017 Feb 2. PMID: 27973680.

5: Zhao X, Wu T, Chang CF, Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J. Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain Behav Immun. 2015 May;46:293-310. doi: 10.1016/j.bbi.2015.02.011. Epub 2015 Feb 16. PMID: 25697396; PMCID: PMC4422065.

6: Iizuka Y, Kuwahara A, Karaki S. Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon. J Physiol Sci. 2014 Mar;64(2):85-96. doi: 10.1007/s12576-013-0295-2. Epub 2013 Oct 30. PMID: 24170253.

7: Ehrlich AT, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. Mol Pharmacol. 2013 Sep;84(3):476-86. doi: 10.1124/mol.113.087288. Epub 2013 Jul 10. PMID: 23842570.

8: Birrell MA, Maher SA, Buckley J, Dale N, Bonvini S, Raemdonck K, Pullen N, Giembycz MA, Belvisi MG. Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor. Br J Pharmacol. 2013 Jan;168(1):129-38. doi: 10.1111/j.1476-5381.2012.02088.x. PMID: 22747912; PMCID: PMC3570009.

9: Jin J, Chang Y, Wei W, He YF, Hu SS, Wang D, Wu YJ. Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro. Acta Pharmacol Sin. 2012 May;33(5):701-9. doi: 10.1038/aps.2012.13. PMID: 22555372; PMCID: PMC4010354.

10: Palazzo E, Guida F, Gatta L, Luongo L, Boccella S, Bellini G, Marabese I, de Novellis V, Rossi F, Maione S. EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat. Mol Pain. 2011 Oct 24;7:82. doi: 10.1186/1744-8069-7-82. PMID: 22023852; PMCID: PMC3250942.

11: Buckley J, Birrell MA, Maher SA, Nials AT, Clarke DL, Belvisi MG. EP4 receptor as a new target for bronchodilator therapy. Thorax. 2011 Dec;66(12):1029-35. doi: 10.1136/thx.2010.158568. Epub 2011 May 23. PMID: 21606476; PMCID: PMC3221321.

12: Mori A, Ito S, Morioka M, Aso H, Kondo M, Sokabe M, Hasegawa Y. Effects of specific prostanoid EP receptor agonists on cell proliferation and intracellular Ca(2+) concentrations in human airway smooth muscle cells. Eur J Pharmacol. 2011 May 20;659(1):72-8. doi: 10.1016/j.ejphar.2011.03.001. Epub 2011 Mar 17. PMID: 21397595.

13: Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T, Hayashi I, Sugimoto Y, Narumiya S, Saigenji K, Majima M. Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying. Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1078-86. doi: 10.1152/ajpgi.00524.2009. Epub 2010 Aug 26. PMID: 20798358.

14: Iyú D, Glenn JR, White AE, Johnson AJ, Fox SC, Heptinstall S. The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. Platelets. 2010;21(5):329-42. doi: 10.3109/09537101003718065. PMID: 20433310.

15: Hattori R, Shimizu S, Majima Y, Shimizu T. Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. Ann Otol Rhinol Laryngol. 2009 Jul;118(7):536-41. doi: 10.1177/000348940911800714. PMID: 19708495.

16: Matsumoto-Miyai K, Kagase A, Murakawa Y, Momota Y, Kawatani M. Extracellular Ca2+ regulates the stimulus-elicited ATP release from urothelium. Auton Neurosci. 2009 Oct 5;150(1-2):94-9. doi: 10.1016/j.autneu.2009.05.253. Epub 2009 Jun 13. PMID: 19525154.

17: Saeki T, Ota T, Aihara M, Araie M. Effects of prostanoid EP agonists on mouse intraocular pressure. Invest Ophthalmol Vis Sci. 2009 May;50(5):2201-8. doi: 10.1167/iovs.08-2800. Epub 2008 Dec 30. PMID: 19117925.

18: Wright CL, Burks SR, McCarthy MM. Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates. Dev Neurobiol. 2008 Oct;68(12):1406-19. doi: 10.1002/dneu.20665. PMID: 18726914; PMCID: PMC2725403.

19: Wang X, Momota Y, Yanase H, Narumiya S, Maruyama T, Kawatani M. Urothelium EP1 receptor facilitates the micturition reflex in mice. Biomed Res. 2008 Apr;29(2):105-11. doi: 10.2220/biomedres.29.105. PMID: 18480552.

20: Wise H. Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells. Eur J Pharmacol. 2006 Mar 27;535(1-3):69-77. doi: 10.1016/j.ejphar.2006.02.018. Epub 2006 Mar 20. PMID: 16545798.