WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 577903

CAS#: 438-60-8

Description: Protriptyline is a tricyclic antidepressant similar in action and side effects to Imipramine. It may produce excitation.

Chemical Structure

CAS# 438-60-8

Theoretical Analysis

MedKoo Cat#: 577903
Name: Protriptyline
CAS#: 438-60-8
Chemical Formula: C19H21N
Exact Mass: 263.17
Molecular Weight: 263.380
Elemental Analysis: C, 86.64; H, 8.04; N, 5.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Protriptyline

IUPAC/Chemical Name: 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-


InChi Code: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

SMILES Code: CNCCCC1c2ccccc2C=Cc3ccccc13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 263.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chang HT, Chou CT, Yu CC, Tsai JY, Sun TK, Liang WZ, Lin KL, Tseng HW, Kuo CC, Chen FA, Kuo DH, Pan CC, Ho CM, Shieh P, Jan CR. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. doi: 10.3109/10799893.2014.1000464. Epub 2015 Jun 22. PubMed PMID: 26096164.

2: Bansode SB, Jana AK, Batkulwar KB, Warkad SD, Joshi RS, Sengupta N, Kulkarni MJ. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196. doi: 10.1371/journal.pone.0105196. eCollection 2014. PubMed PMID: 25141174; PubMed Central PMCID: PMC4139341.

3: Jo SH, Hong HK, Chong SH, Choe H. Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel. Life Sci. 2008 Jan 30;82(5-6):331-40. doi: 10.1016/j.lfs.2007.12.004. Epub 2008 Jan 11. PubMed PMID: 18191158.

4: Hanzel DA, Proia NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest. 1991 Aug;100(2):416-21. PubMed PMID: 1864117.