AA29504

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466126

CAS#: 945828-50-2

Description: AA29504 is a novel potent agonist and positive allosteric modulator (Ago-PAM) of δ-GABAARs.


Chemical Structure

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AA29504
CAS# 945828-50-2

Theoretical Analysis

MedKoo Cat#: 466126
Name: AA29504
CAS#: 945828-50-2
Chemical Formula: C19H25N3O2
Exact Mass: 327.19
Molecular Weight: 327.428
Elemental Analysis: C, 69.70; H, 7.70; N, 12.83; O, 9.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AA29504; AA 29504; AA-29504;

IUPAC/Chemical Name: ethyl (2-amino-4-((2,4,6-trimethylbenzyl)amino)phenyl)carbamate

InChi Key: SCOOTUMXCXKEAD-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25N3O2/c1-5-24-19(23)22-18-7-6-15(10-17(18)20)21-11-16-13(3)8-12(2)9-14(16)4/h6-10,21H,5,11,20H2,1-4H3,(H,22,23)

SMILES Code: O=C(OCC)NC1=CC=C(NCC2=C(C)C=C(C)C=C2C)C=C1N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 327.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sikstus S, Benkherouf AY, Soini SL, Uusi-Oukari M. The Influence of AA29504 on GABAA Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity. Neurochem Res. 2022 Mar;47(3):667-678. doi: 10.1007/s11064-021-03475-y. Epub 2021 Nov 2. PMID: 34727270; PMCID: PMC8847198.

2: McGrath M, Tolia M, Raines DE. The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents. Pharmacol Rep. 2020 Feb;72(1):260-266. doi: 10.1007/s43440-019-00031-y. Epub 2020 Jan 8. PMID: 32016849; PMCID: PMC7006677.

3: Olander ER, Madjroh N, Bunch L, Söderhielm PC, Jensen AA. Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem Pharmacol. 2018 Apr;150:305-319. doi: 10.1016/j.bcp.2018.02.015. Epub 2018 Feb 16. PMID: 29454619.

4: Falk-Petersen CB, Søgaard R, Madsen KL, Klein AB, Frølund B, Wellendorph P. Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes. Basic Clin Pharmacol Toxicol. 2017 Aug;121(2):119-129. doi: 10.1111/bcpt.12778. Epub 2017 May 25. PMID: 28299900.

5: Vardya I, Hoestgaard-Jensen K, Nieto-Gonzalez JL, Dósa Z, Boddum K, Holm MM, Wolinsky TD, Jones KA, Dalby NO, Ebert B, Jensen K. Positive modulation of δ-subunit containing GABA(A) receptors in mouse neurons. Neuropharmacology. 2012 Sep;63(3):469-79. doi: 10.1016/j.neuropharm.2012.04.023. Epub 2012 Apr 30. PMID: 22579928.

6: Hoestgaard-Jensen K, Dalby NO, Wolinsky TD, Murphey C, Jones KA, Rottländer M, Frederiksen K, Watson WP, Jensen K, Ebert B. Pharmacological characterization of a novel positive modulator at alpha 4 beta 3 delta-containing extrasynaptic GABA(A) receptors. Neuropharmacology. 2010 Mar-Apr;58(4-5):702-11. doi: 10.1016/j.neuropharm.2009.12.023. Epub 2010 Jan 12. PMID: 20060846.