WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 466098

CAS#: unknown

Description: HAM-1 is an Aha1-stimulated Hsp90 ATPase activity inhibitor.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 466098
Name: HAM-1
CAS#: unknown
Chemical Formula: C22H14F2N6O
Exact Mass: 416.12
Molecular Weight: 416.392
Elemental Analysis: C, 63.46; H, 3.39; F, 9.13; N, 20.18; O, 3.84

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: HAM-1; HAM1; HAM 1;

IUPAC/Chemical Name: 6-amino-3-(4-fluorophenyl)-4-(3-(4-fluorophenyl)-1H-pyrazol-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile


InChi Code: InChI=1S/C22H14F2N6O/c23-13-5-1-11(2-6-13)19-16(10-27-28-19)17-15(9-25)21(26)31-22-18(17)20(29-30-22)12-3-7-14(24)8-4-12/h1-8,10,17H,26H2,(H,27,28)(H,29,30)

SMILES Code: NC1=C(C#N)C(C2=CNN=C2C3=CC=C(F)C=C3)C(C(C4=CC=C(F)C=C4)=NN5)=C5O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 416.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fan Y, Yan J, Lai D, Yang H, Xue G, He A, Guo T, Chen L, Cheng XB, Xiang DB, Ruan J, Cheng J. Genome-wide identification, expression analysis, and functional study of the GRAS transcription factor family and its response to abiotic stress in sorghum [Sorghum bicolor (L.) Moench]. BMC Genomics. 2021 Jul 6;22(1):509. doi: 10.1186/s12864-021-07848-z. PMID: 34229611; PMCID: PMC8259154.

2: Wang Y, Hardin H, Chu YH, Esbona K, Zhang R, Lloyd RV. Long Non-coding RNA Expression in Anaplastic Thyroid Carcinomas. Endocr Pathol. 2019 Dec;30(4):262-269. doi: 10.1007/s12022-019-09589-y. PMID: 31468286.

3: Offenburger SL, Bensaddek D, Murillo AB, Lamond AI, Gartner A. Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development. Sci Rep. 2017 Jun 28;7(1):4314. doi: 10.1038/s41598-017-04375-4. PMID: 28659600; PMCID: PMC5489525.