WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510259
Description: AZD1283 is a potent antagonist of the P2Y12 receptor. In a modified Folts model in dog, both AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 μg/kg/min. The doses that induced a larger than 3-fold increase in bleeding time were 33 μg/kg/min. Thus, the therapeutic index (TI) was ≥ 10. On the basis of these data, AZD1283 was progressed into human clinical trials as candidate drug.
MedKoo Cat#: 510259
Chemical Formula: C23H26N4O5S
Exact Mass: 470.16239
Molecular Weight: 470.54134
Elemental Analysis: C, 58.71; H, 5.57; N, 11.91; O, 17.00; S, 6.81
AZD1283, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: AZD-1283; AZD1283; AZD 1283.
IUPAC/Chemical Name: ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate.
InChi Key: NEMHKCNXXRQYRF-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H26N4O5S/c1-3-32-23(29)20-13-19(14-24)21(25-16(20)2)27-11-9-18(10-12-27)22(28)26-33(30,31)15-17-7-5-4-6-8-17/h4-8,13,18H,3,9-12,15H2,1-2H3,(H,26,28)
SMILES Code: O=C(OCC)C1=C(C)N=C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)C(C#N)=C1
The following data is based on the product molecular weight 470.54134 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bach P, Antonsson T, Bylund R, BjÃ¶rkman JA, Ã–sterlund K, Giordanetto F, van Giezen JJ, Andersen SM, Zachrisson H, Zetterberg F. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56(17):7015-24. doi: 10.1021/jm400820m. Epub 2013 Aug 29. PubMed PMID: 23899349.