WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510313
CAS#: 864082-47-3
Description: GSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.
MedKoo Cat#: 510313
Name: GSK429286A
CAS#: 864082-47-3
Chemical Formula: C21H16F4N4O2
Exact Mass: 432.12094
Molecular Weight: 432.37
Elemental Analysis: C, 58.34; H, 3.73; F, 17.58; N, 12.96; O, 7.40
Synonym: GSK429286A; GSK 429286A; GSK-429286A.
IUPAC/Chemical Name: N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
InChi Key: OLIIUAHHAZEXEX-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)
SMILES Code: O=C(C(C(C1=CC=C(C(F)(F)F)C=C1)C2)=C(C)NC2=O)NC3=CC4=C(NN=C4)C=C3F
1: Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60. doi: 10.1042/BJ20091035. PubMed PMID: 19740074; PubMed Central PMCID: PMC3759966.