CL-387785
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MedKoo CAT#: 406106

CAS#: 194423-06-8

Description: CL-387785, also known as EKI-785 , is a n irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM). CL-387785 covalently bound to EGF-R. It also specifically inhibited kinase activity of the protein (IC50 = 370+/-120 pM), blocked EGF-stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2, and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice (when given orally at 80 mg/kg/day for 10 days, daily). CL-387,785 is useful for studying the interaction of small molecules with EGF-R and may have clinical utility.


Price and Availability

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Price

10mg
USD 150
100mg
USD 650
1g
USD 2250
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25mg
USD 250
200mg
USD 950
2g
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Size
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50mg
USD 450
500mg
USD 1650
5g
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CL-387785, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406106
Name: CL-387785
CAS#: 194423-06-8
Chemical Formula: C18H13BrN4O
Exact Mass: 380.02727
Molecular Weight: 381.23
Elemental Analysis: C, 56.71; H, 3.44; Br, 20.96; N, 14.70; O, 4.20


Synonym: CL387785; CL 387785; CL-387785; EKI785; EK-I785; EK I785.

IUPAC/Chemical Name: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide

InChi Key: BTYYWOYVBXILOJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23)

SMILES Code: CC#CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

  
 
 
 


References

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