P005091
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406577

CAS#: 882257-11-6

Description: P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μ M). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo . The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention.


Chemical Structure

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P005091
CAS# 882257-11-6

Theoretical Analysis

MedKoo Cat#: 406577
Name: P005091
CAS#: 882257-11-6
Chemical Formula: C12H7Cl2NO3S2
Exact Mass: 346.92444
Molecular Weight: 348.22
Elemental Analysis: C, 41.39; H, 2.03; Cl, 20.36; N, 4.02; O, 13.78; S, 18.42

Price and Availability

Size Price Availability Quantity
10.0mg USD 310.0 2 Weeks
25.0mg USD 550.0 2 Weeks
50.0mg USD 750.0 2 Weeks
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Synonym: P005091; P-005091; P 005091; P5091; P-5091; P 5091.

IUPAC/Chemical Name: 1-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethanone

InChi Key: LKZLGMAAKNEGCH-UHFFFAOYSA-N

InChi Code: 1-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethanone InChI=1S/C12H7Cl2NO3S2/c1-6(16)10-5-8(15(17)18)12(20-10)19-9-4-2-3-7(13)11(9)14/h2-5H,1H3

SMILES Code: CC(C1=CC([N+]([O-])=O)=C(SC2=CC=CC(Cl)=C2Cl)S1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 348.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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P005091

10.0mg / USD 310.0


Additional Information