WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406566
Description: ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (ClkÂ’s) and the dual-specificity tyrosine phosphorylation-regulated kinases (DyrkÂ’s) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome.
MedKoo Cat#: 406566
Chemical Formula: C19H17N3O3
Exact Mass: 335.12699
Molecular Weight: 335.35658
Elemental Analysis: C, 68.05; H, 5.11; N, 12.53; O, 14.31
ML167, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: ML167; ML-167; ML 167; CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654
IUPAC/Chemical Name: (5-(4-(((5-methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol
InChi Key: ROCFOIBAEVAOLQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
SMILES Code: OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1
The following data is based on the product molecular weight 335.35658 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Rosenthal AS, Tanega C, Shen M, Mott BT, Bougie JM, Nguyen DT, Misteli T, Auld DS, Maloney DJ, Thomas CJ. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2010 Mar 29 [updated 2011 Mar 3]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK56236/ PubMed PMID: 21735605.