WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556065
CAS#: 854847-61-3
Description: HLY78 is an activator of the Wnt/β-Catenin signaling pathway. HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats.
MedKoo Cat#: 556065
Name: HLY78
CAS#: 854847-61-3
Chemical Formula: C17H17NO2
Exact Mass: 267.1259
Molecular Weight: 267.328
Elemental Analysis: C, 76.38; H, 6.41; N, 5.24; O, 11.97
Synonym: HLY78; HLY-78; HLY 78;
IUPAC/Chemical Name: 4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine
InChi Key: FAZZYPIBZBGQSH-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3
SMILES Code: CN1C2=C(CC)C=CC=C2C3=CC(OCO4)=C4C=C3C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 267.328 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ma Y, Zhang P, Zhang Q, Wang X, Miao Q, Lyu X, Cui B, Ma H. Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer. Oncol Lett. 2021 Oct;22(4):688. doi: 10.3892/ol.2021.12949. Epub 2021 Jul 29. Erratum in: Oncol Lett. 2022 Jan;23(1):34. PMID: 34457043; PMCID: PMC8358739.
2: Luo X, Li L, Zheng W, Gu L, Zhang X, Li Y, Xie Z, Cheng Y. HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats. Brain Res Bull. 2020 Sep;162:107-114. doi: 10.1016/j.brainresbull.2020.06.003. Epub 2020 Jun 18. PMID: 32565130.
3: Luo X, Li L, Xu W, Cheng Y, Xie Z. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neurosci Bull. 2020 Oct;36(10):1171-1181. doi: 10.1007/s12264-020-00532-4. Epub 2020 Jun 20. PMID: 32562163; PMCID: PMC7532258.
4: Si J, Zhang J, Gan L, Guo M, Xie Y, Di C, Sun C, Wang F, Yan J, Zhang H. The effects of the Wnt/β‑catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation. Oncol Rep. 2020 Jul;44(1):303-312. doi: 10.3892/or.2020.7581. Epub 2020 Apr 10. PMID: 32319660.
5: Ge Z, Yang Y, Zhou X, Zhang J, Li B, Wang X, Luo X. Overexpression of the hyperplasia suppressor gene inactivates airway fibroblasts obtained from a rat model of chronic obstructive pulmonary disease by inhibiting the Wnt signaling pathway. Mol Med Rep. 2019 Sep;20(3):2754-2762. doi: 10.3892/mmr.2019.10504. Epub 2019 Jul 15. PMID: 31322244; PMCID: PMC6691245.
6: Chen DZ, Yang BJ, He XL, Fan SR, Cai JY, Jing CX, Zhang H, Zhang Y, Li L, Hao XJ. Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/β-catenin signalling pathway agonists. Bioorg Chem. 2019 Mar;84:285-294. doi: 10.1016/j.bioorg.2018.11.020. Epub 2018 Nov 19. PMID: 30529846.
7: Si J, Zhou R, Zhao B, Xie Y, Gan L, Zhang J, Wang Y, Zhou X, Ren X, Zhang H. Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity. Toxicology. 2019 Jan 1;411:143-153. doi: 10.1016/j.tox.2018.10.004. Epub 2018 Oct 12. PMID: 30321647.
8: Chen D, Zhang H, Jing C, He X, Yang B, Cai J, Zhou Y, Song X, Li L, Hao X. Efficient synthesis of new phenanthridine Wnt/β-catenin signaling pathway agonists. Eur J Med Chem. 2018 Sep 5;157:1491-1499. doi: 10.1016/j.ejmech.2018.08.064. Epub 2018 Aug 28. PMID: 30282321.
9: Venkatadri R, Iyer AKV, Kaushik V, Azad N. A novel resveratrol-salinomycin combination sensitizes ER-positive breast cancer cells to apoptosis. Pharmacol Rep. 2017 Aug;69(4):788-797. doi: 10.1016/j.pharep.2017.03.024. Epub 2017 Apr 7. PMID: 28605700.
10: Yakisich JS, Azad N, Kaushik V, O'Doherty GA, Iyer AK. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol. 2017 Mar;39(3):1010428317694310. doi: 10.1177/1010428317694310. PMID: 28351327.
11: Guo X, Zhang L, Fan Y, Zhang D, Qin L, Dong S, Li G. Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis. Oncol Res. 2017 May 24;25(5):799-808. doi: 10.3727/096504016X14783691306605. Epub 2016 Nov 8. PMID: 27983927; PMCID: PMC7841135.
12: Chen DZ, Jing CX, Cai JY, Wu JB, Wang S, Yin JL, Li XN, Li L, Hao XJ. Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/β-Catenin Signaling Pathway Agonists. J Nat Prod. 2016 Jan 22;79(1):180-8. doi: 10.1021/acs.jnatprod.5b00825. Epub 2015 Dec 29. PMID: 26714198.
13: Wang S, Yin J, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X, Li L. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85. doi: 10.1038/nchembio.1309. Epub 2013 Jul 28. PMID: 23892894.
