MedKoo Biosciences

HLY78
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556065

CAS#: 854847-61-3

Description: HLY78 is an activator of the Wnt/β-Catenin signaling pathway. HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats.

Chemical Structure

HLY78

CAS# 854847-61-3

Instruction

Theoretical Analysis

MedKoo Cat#: 556065
Name: HLY78
CAS#: 854847-61-3
Chemical Formula: C17H17NO2
Exact Mass: 267.13
Molecular Weight: 267.328
Elemental Analysis: C, 76.38; H, 6.41; N, 5.24; O, 11.97

Price and Availability

Size	Price	Availability
25mg	USD 250	2 Weeks
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1350	2 Weeks
500mg	USD 2850	2 Weeks
1g	USD 3850	2 Weeks
2g	USD 6450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: HLY78; HLY-78; HLY 78;

IUPAC/Chemical Name: 4-Ethyl-5,6-Dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine

InChi Key: FAZZYPIBZBGQSH-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3

SMILES Code: CN1C2=C(CC)C=CC=C2C3=CC(OCO4)=C4C=C3C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 267.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ma Y, Zhang P, Zhang Q, Wang X, Miao Q, Lyu X, Cui B, Ma H. Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer. Oncol Lett. 2021 Oct;22(4):688. doi: 10.3892/ol.2021.12949. Epub 2021 Jul 29. Erratum in: Oncol Lett. 2022 Jan;23(1):34. PMID: 34457043; PMCID: PMC8358739.

2: Luo X, Li L, Zheng W, Gu L, Zhang X, Li Y, Xie Z, Cheng Y. HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats. Brain Res Bull. 2020 Sep;162:107-114. doi: 10.1016/j.brainresbull.2020.06.003. Epub 2020 Jun 18. PMID: 32565130.

3: Luo X, Li L, Xu W, Cheng Y, Xie Z. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neurosci Bull. 2020 Oct;36(10):1171-1181. doi: 10.1007/s12264-020-00532-4. Epub 2020 Jun 20. PMID: 32562163; PMCID: PMC7532258.

4: Si J, Zhang J, Gan L, Guo M, Xie Y, Di C, Sun C, Wang F, Yan J, Zhang H. The effects of the Wnt/β‑catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation. Oncol Rep. 2020 Jul;44(1):303-312. doi: 10.3892/or.2020.7581. Epub 2020 Apr 10. PMID: 32319660.

5: Ge Z, Yang Y, Zhou X, Zhang J, Li B, Wang X, Luo X. Overexpression of the hyperplasia suppressor gene inactivates airway fibroblasts obtained from a rat model of chronic obstructive pulmonary disease by inhibiting the Wnt signaling pathway. Mol Med Rep. 2019 Sep;20(3):2754-2762. doi: 10.3892/mmr.2019.10504. Epub 2019 Jul 15. PMID: 31322244; PMCID: PMC6691245.

6: Chen DZ, Yang BJ, He XL, Fan SR, Cai JY, Jing CX, Zhang H, Zhang Y, Li L, Hao XJ. Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/β-catenin signalling pathway agonists. Bioorg Chem. 2019 Mar;84:285-294. doi: 10.1016/j.bioorg.2018.11.020. Epub 2018 Nov 19. PMID: 30529846.

7: Si J, Zhou R, Zhao B, Xie Y, Gan L, Zhang J, Wang Y, Zhou X, Ren X, Zhang H. Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity. Toxicology. 2019 Jan 1;411:143-153. doi: 10.1016/j.tox.2018.10.004. Epub 2018 Oct 12. PMID: 30321647.

8: Chen D, Zhang H, Jing C, He X, Yang B, Cai J, Zhou Y, Song X, Li L, Hao X. Efficient synthesis of new phenanthridine Wnt/β-catenin signaling pathway agonists. Eur J Med Chem. 2018 Sep 5;157:1491-1499. doi: 10.1016/j.ejmech.2018.08.064. Epub 2018 Aug 28. PMID: 30282321.

9: Venkatadri R, Iyer AKV, Kaushik V, Azad N. A novel resveratrol-salinomycin combination sensitizes ER-positive breast cancer cells to apoptosis. Pharmacol Rep. 2017 Aug;69(4):788-797. doi: 10.1016/j.pharep.2017.03.024. Epub 2017 Apr 7. PMID: 28605700.

10: Yakisich JS, Azad N, Kaushik V, O'Doherty GA, Iyer AK. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol. 2017 Mar;39(3):1010428317694310. doi: 10.1177/1010428317694310. PMID: 28351327.

11: Guo X, Zhang L, Fan Y, Zhang D, Qin L, Dong S, Li G. Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis. Oncol Res. 2017 May 24;25(5):799-808. doi: 10.3727/096504016X14783691306605. Epub 2016 Nov 8. PMID: 27983927; PMCID: PMC7841135.

12: Chen DZ, Jing CX, Cai JY, Wu JB, Wang S, Yin JL, Li XN, Li L, Hao XJ. Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/β-Catenin Signaling Pathway Agonists. J Nat Prod. 2016 Jan 22;79(1):180-8. doi: 10.1021/acs.jnatprod.5b00825. Epub 2015 Dec 29. PMID: 26714198.

13: Wang S, Yin J, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X, Li L. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85. doi: 10.1038/nchembio.1309. Epub 2013 Jul 28. PMID: 23892894.

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