W-2-9

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465938

CAS#: unknown

Description: W-2-9 is a novel bidentate-galactose prodrug of W-105, releasing the antitumor pharmacophore in the presence of GSH (mimic the condition of the tumor cell) and maintaining the low-toxic structures in the absence of GSH (mimic the condition of the normal cell).


Chemical Structure

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W-2-9
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465938
Name: W-2-9
CAS#: unknown
Chemical Formula: C62H83N13O18S2
Exact Mass: 1361.542
Molecular Weight: 1362.539
Elemental Analysis: C, 54.65; H, 6.14; N, 13.36; O, 21.14; S, 4.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: W-2-9; W2-9; W 2-9; W-29; W-2 9; W29; W 2 9;

IUPAC/Chemical Name: 6-oxo-1-(1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-4-yl)-4-(((1-((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)methyl)-2,8-dioxa-11,12-dithia-5-azatetradecan-14-yl 4-(2-((1-(2-((1R,3S,4S)-4-methyl-3-(prop-1-en-2-yl)-4-vinylcyclohexyl)allyl)-1H-1,2,3-triazol-4-yl)methyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)piperazine-1-carboxylate

InChi Key: CBVIUABLTMXLIQ-IDQLJWTISA-N

InChi Code: InChI=1S/C62H83N13O18S2/c1-6-62(5)13-12-37(22-45(62)35(2)3)36(4)23-72-24-38(64-67-72)25-73-57(85)43-9-7-8-42-46(11-10-44(50(42)43)58(73)86)70-14-16-71(17-15-70)61(87)91-19-21-95-94-20-18-88-34-49(78)63-41(32-89-30-39-26-74(68-65-39)59-55(83)53(81)51(79)47(28-76)92-59)33-90-31-40-27-75(69-66-40)60-56(84)54(82)52(80)48(29-77)93-60/h6-11,24,26-27,37,41,45,47-48,51-56,59-60,76-77,79-84H,1-2,4,12-23,25,28-34H2,3,5H3,(H,63,78)/t37-,41?,45+,47-,48+,51+,52-,53+,54-,55-,56+,59-,60+,62-/m1/s1

SMILES Code: O=C(N1CCN(C2=CC=C(C3=C4C=CC=C32)C(N(CC5=CN(CC([C@H]6C[C@@H](C(C)=C)[C@@](C=C)(C)CC6)=C)N=N5)C4=O)=O)CC1)OCCSSCCOCC(NC(COCC7=CN([C@@H]8[C@@H](O)[C@H](O)[C@H](O)[C@H](CO)O8)N=N7)COCC9=CN([C@H]%10[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O%10)N=N9)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 1362.539 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wang M, Li Z, Liu F, Yi Q, Pu C, Li Y, Luo T, Liang J, Wang J. Development of Asialoglycoprotein-Mediated Hepatocyte-Targeting Antitumor Prodrugs Triggered by Glutathione. J Med Chem. 2021 Oct 14;64(19):14793-14808. doi: 10.1021/acs.jmedchem.1c01365. Epub 2021 Oct 1. PMID: 34595917.