BIX01294 HCl

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MedKoo CAT#: 406565

CAS#: 1392399-03-9 ( HCl)

Description: BIX01294 is a potent chemical inhibitor of G9a methyltransferase that catalyzes the mono-and di-methylation of the lysine 9 residue of histone H3. BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells. BIX01294 enhances the cardiac potential of bone marrow cells.

Chemical Structure

BIX01294 HCl
CAS# 1392399-03-9 ( HCl)

Theoretical Analysis

MedKoo Cat#: 406565
Name: BIX01294 HCl
CAS#: 1392399-03-9 ( HCl)
Chemical Formula: C28H41Cl3N6O2
Exact Mass:
Molecular Weight: 600.026
Elemental Analysis: C, 56.05; H, 6.89; Cl, 17.72; N, 14.01; O, 5.33

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 650 Same day
200mg USD 950 Same day
500mg USD 1650 Same day
1g USD 2450 Same day
2g USD 3850 Same day
5g USD 6450 Same day
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Pricing updated 2021-03-01. Prices are subject to change without notice.

BIX01294 HCl, purity > 98%, is in stock. The same day shipping after order is received.

Related CAS #: 935693-62-2 (free base)   1392399-03-9 ( HCl)    

Synonym: BIX01294; BIX-01294; BIX 01294; BIX01294 HCl

IUPAC/Chemical Name: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride.


InChi Code: InChI=1S/C28H38N6O2.3ClH/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H


White to off-white solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Preparing Stock Solutions

The following data is based on the product molecular weight 600.026 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pang AL, Title AC, Rennert OM. Modulation of microRNA expression in human lung cancer cells by the G9a histone methyltransferase inhibitor BIX01294. Oncol Lett. 2014 Jun;7(6):1819-1825. Epub 2014 Apr 4. PubMed PMID: 24932239; PubMed Central PMCID: PMC4049738.

2: Tsuda H, Zhao N, Imai K, Ochiai K, Yang P, Suzuki N. BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells. Bosn J Basic Med Sci. 2013 Nov;13(4):271-5. PubMed PMID: 24289765.

3: Mezentseva NV, Yang J, Kaur K, Iaffaldano G, Rémond MC, Eisenberg CA, Eisenberg LM. The histone methyltransferase inhibitor BIX01294 enhances the cardiac potential of bone marrow cells. Stem Cells Dev. 2013 Feb 15;22(4):654-67. doi: 10.1089/scd.2012.0181. Epub 2012 Nov 7. PubMed PMID: 22994322; PubMed Central PMCID: PMC3564468.

4: Imai K, Togami H, Okamoto T. Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294. J Biol Chem. 2010 May 28;285(22):16538-45. doi: 10.1074/jbc.M110.103531. Epub 2010 Mar 24. PubMed PMID: 20335163; PubMed Central PMCID: PMC2878073.

Additional Information

BIX01294 free base
Chemical Formula: C28H38N6O2
Exact Mass: 490.3056
Molecular Weight: 490.6520
Elemental Analysis: C, 68.54; H, 7.81; N, 17.13; O, 6.52