ONO-7684

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465898

CAS#: unknown

Description: ONO-7684 is a FXIa inhibitor.


Chemical Structure

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ONO-7684
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 465898
Name: ONO-7684
CAS#: unknown
Chemical Formula: C23H16ClF2N9O
Exact Mass: 507.1134
Molecular Weight: 507.8898
Elemental Analysis: C, 54.39; H, 3.18; Cl, 6.98; F, 7.48; N, 24.82; O, 3.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ONO-7684; ONO7684; ONO 7684;

IUPAC/Chemical Name: (R)-3-(2-(6-amino-2-fluoropyridin-3-yl)-5-fluoro-1H-imidazol-4-yl)-7-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-2,3-dihydroindolizin-5(1H)-one

InChi Key: YVACZLFZCFGMPP-QGZVFWFLSA-N

InChi Code: InChI=1S/C23H16ClF2N9O/c24-12-1-4-16(34-10-28-32-33-34)15(9-12)11-7-13-2-5-17(35(13)19(36)8-11)20-22(26)31-23(30-20)14-3-6-18(27)29-21(14)25/h1,3-4,6-10,17H,2,5H2,(H2,27,29)(H,30,31)/t17-/m1/s1

SMILES Code: O=C(N([C@@H](C1=C(F)NC(C2=C(F)N=C(N)C=C2)=N1)CC3)C3=C4)C=C4C5=C(N6C=NN=N6)C=CC(Cl)=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 507.8898 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Beale D, Dennison J, Boyce M, Mazzo F, Honda N, Smith P, Bruce M. ONO-7684 a novel oral FXIa inhibitor: Safety, tolerability, pharmacokinetics and pharmacodynamics in a first-in-human study. Br J Clin Pharmacol. 2021 Aug;87(8):3177-3189. doi: 10.1111/bcp.14732. Epub 2021 Jan 23. PMID: 33450079; PMCID: PMC8359378.