WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465898
Description: ONO-7684 is a FXIa inhibitor.
MedKoo Cat#: 465898
Chemical Formula: C23H16ClF2N9O
Exact Mass: 507.1134
Molecular Weight: 507.8898
Elemental Analysis: C, 54.39; H, 3.18; Cl, 6.98; F, 7.48; N, 24.82; O, 3.15
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ONO-7684; ONO7684; ONO 7684;
IUPAC/Chemical Name: (R)-3-(2-(6-amino-2-fluoropyridin-3-yl)-5-fluoro-1H-imidazol-4-yl)-7-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-2,3-dihydroindolizin-5(1H)-one
InChi Key: YVACZLFZCFGMPP-QGZVFWFLSA-N
InChi Code: InChI=1S/C23H16ClF2N9O/c24-12-1-4-16(34-10-28-32-33-34)15(9-12)11-7-13-2-5-17(35(13)19(36)8-11)20-22(26)31-23(30-20)14-3-6-18(27)29-21(14)25/h1,3-4,6-10,17H,2,5H2,(H2,27,29)(H,30,31)/t17-/m1/s1
SMILES Code: O=C(N([C@@H](C1=C(F)NC(C2=C(F)N=C(N)C=C2)=N1)CC3)C3=C4)C=C4C5=C(N6C=NN=N6)C=CC(Cl)=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 507.8898 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Beale D, Dennison J, Boyce M, Mazzo F, Honda N, Smith P, Bruce M. ONO-7684 a novel oral FXIa inhibitor: Safety, tolerability, pharmacokinetics and pharmacodynamics in a first-in-human study. Br J Clin Pharmacol. 2021 Aug;87(8):3177-3189. doi: 10.1111/bcp.14732. Epub 2021 Jan 23. PMID: 33450079; PMCID: PMC8359378.