CC-99677
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 408167

CAS#: 1887069-10-4

Description: CC-99677 is a Novel, Oral, Selective MK2 Inhibitor with Sustainable Multi-Cytokine Inhibition for the Treatment of Ankylosing Spondylitis and Other Inflammatory Diseases.

Chemical Structure

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CC-99677
CAS# 1887069-10-4
Instruction

Theoretical Analysis

MedKoo Cat#: 408167
Name: CC-99677
CAS#: 1887069-10-4
Chemical Formula: C22H20ClN5O3S
Exact Mass: 469.10
Molecular Weight: 469.944
Elemental Analysis: C, 56.23; H, 4.29; Cl, 7.54; N, 14.90; O, 10.21; S, 6.82

Price and Availability

Size Price Availability Quantity
5mg USD 1250 2 Weeks
10mg USD 2250 2 Weeks
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Related CAS #: 1887069-10-4  

Synonym: CC-99677; CC 99677; CC99677; gamcemetinib

IUPAC/Chemical Name: (10R)-3-[[2-Chloro-5-(ethoxymethyl)-4-pyrimidinyl]oxy]-9,10,11,12-tetrahydro-10-methyl-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one

InChi Key: PYOQIOLRFIRRSO-LLVKDONJSA-N

InChi Code: InChI=1S/C22H20ClN5O3S/c1-3-30-10-12-9-25-22(23)28-21(12)31-16-7-4-13-14(27-16)5-6-15-17(13)18-19(32-15)20(29)26-11(2)8-24-18/h4-7,9,11,24H,3,8,10H2,1-2H3,(H,26,29)/t11-/m1/s1

SMILES Code: O=C1N[C@H](C)CNC2=C1SC3=CC=C4N=C(OC5=NC(Cl)=NC=C5COCC)C=CC4=C32

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Inhibitors of p38 are associated with tachyphylaxis in patients with RA and other inflammatory diseases, where early reduction in ex vivo production of cytokines, such as TNF-α, or endogenous inflammatory markers, such as CRP, did not persist despite continued treatment. Thus, p38 inhibitors have not advanced in clinical development. Targets downstream of p38 have been identified to avoid these limitations. The mitogen-activated protein kinase-activated protein kinase-2 (MK2) pathway is activated downstream of p38, and activation of MK2 increases the stability and translation of mRNA of proinflammatory factors (e.g., TNF-α, IL-17, IL-6).

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 469.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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