WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406552

CAS#: 118292-41-4

Description: Tazarotene is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of tazarotene (AGN 190299), by rapid deesterification in animals and man. AGN 190299 (“tazarotenic acid”) binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARγ but shows relative selectivity for RARβ, and RARγ and may modify gene expression. The clinical significance of these findings is unknown.

Chemical Structure

CAS# 118292-41-4

Theoretical Analysis

MedKoo Cat#: 406552
Name: AGN-190299
CAS#: 118292-41-4
Chemical Formula: C19H17NO2S
Exact Mass: 323.098
Molecular Weight: 323.40878
Elemental Analysis: C, 70.56; H, 5.30; N, 4.33; O, 9.89; S, 9.91

Price and Availability

Size Price Availability Quantity
5.0mg USD 265.0 2 Weeks
10.0mg USD 455.0 2 Weeks
25.0mg USD 845.0 2 Weeks
50.0mg USD 1500.0 2 Weeks
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Synonym: AGN 190299; AGN-190299; AGN190299; Tazarotenic acid.

IUPAC/Chemical Name: 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid


InChi Code: InChI=1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22)

SMILES Code: O=C(O)C1=CN=C(C#CC2=CC(C(C)(C)CCS3)=C3C=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 323.40878 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information