WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406552
CAS#: 118292-41-4
Description: Tazarotene is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of tazarotene (AGN 190299), by rapid deesterification in animals and man. AGN 190299 (“tazarotenic acid”) binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARγ but shows relative selectivity for RARβ, and RARγ and may modify gene expression. The clinical significance of these findings is unknown.
MedKoo Cat#: 406552
Name: AGN-190299
CAS#: 118292-41-4
Chemical Formula: C19H17NO2S
Exact Mass: 323.098
Molecular Weight: 323.40878
Elemental Analysis: C, 70.56; H, 5.30; N, 4.33; O, 9.89; S, 9.91
Synonym: AGN 190299; AGN-190299; AGN190299; Tazarotenic acid.
IUPAC/Chemical Name: 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid
InChi Key: IQIBKLWBVJPOQO-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22)
SMILES Code: O=C(O)C1=CN=C(C#CC2=CC(C(C)(C)CCS3)=C3C=C2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 323.40878 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
