WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465739
CAS#: unknown
Description: ON108600 is a TNIK inhibitor. ON108600 showed broad-spectrum anti-proliferative and cytotoxic activity in multiple cancer cell lines while having little or no effect on normal cells. CK2 regulates Akt signaling through phosphorylation and inactivation of PTEN and via direct and specific phosphorylation of Akt at S129. Treatment with ON108600 resulted in dramatic reductions of phosphorylation of PTEN and Akt S129 and downstream targets of Akt in multiple cancer cell lines.
MedKoo Cat#: 465739
Name: ON108600
CAS#: unknown
Chemical Formula: C22H14Cl2N2O6S2
Exact Mass: 535.967
Molecular Weight: 537.382
Elemental Analysis: C, 49.17; H, 2.63; Cl, 13.19; N, 5.21; O, 17.86; S, 11.93
This product is not in stock, which may be available by custom synthesis.
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Synonym: ON108600; ON 108600; ON-108600;
IUPAC/Chemical Name: (Z)-6-((2,6-dichlorobenzyl)sulfonyl)-2-(4-hydroxy-3-nitrobenzylidene)-2H-benzo[b][1,4]thiazin-3(4H)-one
InChi Key: DOMBZVXKSRQDOJ-NKVSQWTQSA-N
InChi Code: InChI=1S/C22H14Cl2N2O6S2/c23-15-2-1-3-16(24)14(15)11-34(31,32)13-5-7-20-17(10-13)25-22(28)21(33-20)9-12-4-6-19(27)18(8-12)26(29)30/h1-10,27H,11H2,(H,25,28)/b21-9-
SMILES Code: ClC1=CC=CC(Cl)=C1CS(=O)(C2=CC(NC(/C(S3)=C/C4=CC=C(O)C([N+]([O-])=O)=C4)=O)=C3C=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 537.382 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
