WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 465715
CAS#: 1351586-50-9
Description: L319, also known as O-8670, Lipid 319; RV-92, is an ionizable lipid. It is useful for Development of Lipidoid Nanoparticles for siRNA, mRNA, and vaccine delivery. Lipid 319 nanoparticles have better delivery efficacy and biodegradability than DLin-MC3-DMA in the delivery of mRNA in vivo. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro
MedKoo Cat#: 465715
Name: L319
CAS#: 1351586-50-9
Chemical Formula: C41H75NO6
Exact Mass: 677.5594
Molecular Weight: 678.052
Elemental Analysis: C, 72.63; H, 11.15; N, 2.07; O, 14.16
Synonym: L319; L 319; L-319; O-8670; O8670; O 8670; RV-92; RV 92; RV92; Lipid 319;
IUPAC/Chemical Name: 1-((E)-non-1-en-1-yl) 17-((E)-non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate
InChi Key: NUHLJRZIHZBRCW-PMLDAKHJSA-N
InChi Code: InChI=1S/C41H75NO6/c1-5-7-9-11-13-21-27-36-46-39(43)32-25-19-15-17-23-30-38(48-41(45)34-29-35-42(3)4)31-24-18-16-20-26-33-40(44)47-37-28-22-14-12-10-8-6-2/h21,27-28,37-38H,5-20,22-26,29-36H2,1-4H3/b27-21+,37-28+
SMILES Code: CN(CCCC(OC(CCCCCCCC(OC/C=C/CCCCCC)=O)CCCCCCCC(O/C=C/CCCCCCC)=O)=O)C
Appearance: Liquid
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 678.052 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
