WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406549
CAS#: 1403783-31-2
Description: Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Nexturastat A possesses antiproliferative effects against melanoma cells. Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dysregulation of histone acetylation can lead to the development of cancers. There is renewed interest in capitalizing new breakthroughs in epigenetic research to address oncology therapy.
MedKoo Cat#: 406549
Name: Nexturastat A
CAS#: 1403783-31-2
Chemical Formula: C19H23N3O3
Exact Mass: 341.17394
Molecular Weight: 341.40422
Elemental Analysis: C, 66.84; H, 6.79; N, 12.31; O, 14.06
Synonym: Nexturastat A
IUPAC/Chemical Name: 4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide
InChi Key: JZWXMCPARMXZQV-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
SMILES Code: O=C(NO)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1
1: Bergman JA, Woan K, Perez-Villarroel P, Villagra A, Sotomayor EM, Kozikowski AP. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9. doi: 10.1021/jm301098e. Epub 2012 Oct 23. PubMed PMID: 23009203; PubMed Central PMCID: PMC3562128.
