Taladegib
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 205529

CAS#: 1258861-20-9 (free base)

Description: Taladegib, also known LY2940680, is a potent Hedgehog inhibitor with potential anticancer activity. LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib.

Chemical Structure

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Taladegib
CAS# 1258861-20-9 (free base)
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 205529
Name: Taladegib
CAS#: 1258861-20-9 (free base)
Chemical Formula: C26H24F4N6O
Exact Mass:
Molecular Weight: 512.5
Elemental Analysis: C, 60.93; H, 4.72; F, 14.83; N, 16.40; O, 3.12

Size Price Shipping out time Quantity
100mg USD 850 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2150 2 Weeks
1g USD 3150 2 Weeks
2g USD 5250 2 Weeks
5g USD 7950 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-02-28. Prices are subject to change without notice.

Taladegib (LY2940680), purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide).

Related CAS #: 1258861-20-9 (free base)   1258861-21-0 (HCl)  

Synonym: LY2940680, LY 2940680, LY-2940680, Taladegib

IUPAC/Chemical Name: 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide

InChi Key: SZBGQDXLNMELTB-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3

SMILES Code: O=C(N(C)C1CCN(C2=NN=C(C3=CC=NN3C)C4=C2C=CC=C4)CC1)C5=CC=C(F)C=C5C(F)(F)F

Appearance:
White solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 512.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bai Q, Shen Y, Jin N, Liu H, Yao X. Molecular modeling study on the dynamical  structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation. Biochim Biophys Acta. 2014 Mar 15. pii: S0304-4165(14)00114-7. doi: 10.1016/j.bbagen.2014.03.010. [Epub ahead of print] PubMed PMID: 24637074.

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Taladegib

100mg / USD 850