C3 DEPTOR Inhibitor

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MedKoo CAT#: 465614

CAS#: 2615911-12-9

Description: C3 DEPTOR Inhibitor is a Icaritin Derivative, and a Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment. Compound C3 exhibited better antimultiple myeloma activity with an IC50 of 1.09 μM for RPMI 8226 cells, induced RPMI 8226 apoptosis, and blocked the cell cycle in the S phase.


Chemical Structure

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C3 DEPTOR Inhibitor
CAS# 2615911-12-9

Theoretical Analysis

MedKoo Cat#: 465614
Name: C3 DEPTOR Inhibitor
CAS#: 2615911-12-9
Chemical Formula: C24H16Cl2FNO4
Exact Mass: 471.04
Molecular Weight: 472.293
Elemental Analysis: C, 61.03; H, 3.41; Cl, 15.01; F, 4.02; N, 2.97; O, 13.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: C3 DEPTOR Inhibitor; C 3 DEPTOR Inhibitor; C-3 DEPTOR Inhibitor;

IUPAC/Chemical Name: 2-(3,4-dichlorophenyl)-9-(3-fluorobenzyl)-3-hydroxy-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one

InChi Key: YHKREPOFPNSZAL-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H16Cl2FNO4/c25-18-6-4-14(9-19(18)26)23-22(30)21(29)16-5-7-20-17(24(16)32-23)11-28(12-31-20)10-13-2-1-3-15(27)8-13/h1-9,30H,10-12H2

SMILES Code: O=C1C(O)=C(C2=CC=C(Cl)C(Cl)=C2)OC3=C4CN(CC5=CC=CC(F)=C5)COC4=CC=C13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 472.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hou Y, Kuang W, Min W, Liu Z, Zhang F, Yuan K, Wang X, Sun C, Cheng H, Wang L, Xiao Y, Pu S, Xin GZ, Yang P. Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment. J Med Chem. 2021 Oct 13. doi: 10.1021/acs.jmedchem.1c00087. Epub ahead of print. PMID: 34644502.